Giant axonal neuropathy

Giant axonal neuropathy
Giant axonal neuropathy has an autosomal recessive pattern of inheritance.

Giant axonal neuropathy is a rare, autosomal recessive[1] neurological disorder that causes disorganization of neurofilaments. Neurofilaments form a structural framework that helps to define the shape and size of neurons and are essential for normal nerve function. A distinguishing feature is its association with kinky, or curly, hair; in such cases it has been called Giant axonal neuropathy with curly hair.[2]

Symptoms and signs

a) Curly hair b) mother’s normal hair c) irregular eyelashes

The clinical presentation of this condition includes the following:[3]

  • Absent tendon reflexes
  • Generalized hypotonia
  • Decreased muscle tone
  • Bell's palsy
  • Pes cavus
  • Scoliosis
  • Pili canalicul
  • Pes planus
  • Motor axonal neuropathy



Genetics

Giant axonal neuropathy results from mutations in the GAN gene, which codes for the protein gigaxonin. This alters the shape of the protein, changing how it interacts with other proteins when organizing the structure of the neuron.

Neurons affected by the altered protein accumulate excess neurofilaments in the axon, the long extension from the nerve cell that transmits its signal to other nerve cells and to muscles. These enlarged or 'giant' axons cannot transmit signals properly, and eventually deteriorate, resulting in the range of neurological anomalies associated with the disorder.

This disease is an autosomal recessive disorder, which means the defective gene is located on an autosome, and both parents must have one copy of the defective gene in order to have a child born with the disorder. The parents of a child with an autosomal recessive disorder are carriers, but are usually not affected by the disorder.

Diagnosis

Giant axonal neuropathy usually appears in infancy or early childhood, and is progressive. Early signs of the disorder often present in the peripheral nervous system, causing individuals with this disorder to have problems walking. Later, normal sensation, coordination, strength, and reflexes become affected. Hearing or vision problems may also occur. Abnormally kinky hair is characteristic of giant axonal neuropathy, appearing in almost all cases. As the disorder progresses, central nervous system becomes involved, which may cause a gradual decline in mental function, loss of control of body movement, and seizures.

Treatment

The management of this condition is based on stimulating intellectual and physical development (physical, occupational and speech therapy)[4]

See also

  • Polyneuropathy in dogs and cats

References

  1. ↑ Donaghy M, Brett EM, Ormerod IE, King RH, Thomas PK (July 1988). "Giant axonal neuropathy: observations on a further patient". Journal of Neurology, Neurosurgery, and Psychiatry. 51 (7): 991–4. doi:10.1136/jnnp.51.7.991. PMC 1033207. PMID 2849642.
  2. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  3. ↑ "Giant axonal neuropathy | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 11 April 2021. Retrieved 18 August 2021.
  4. ↑ RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Giant axonal neuropathy". www.orpha.net. Archived from the original on 17 February 2018. Retrieved 18 August 2021.
Classification
External resources


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