Isoniazid/rifampicin

Isoniazid/rifampicin
Combination of
IsoniazidAnti-tuberculosis medication
RifampicinAnti-tuberculosis medication
Names
Trade namesIsonaRif, Rifamate, others
Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
    Defined daily dosenot established[1]
    External links
    US NLMIsoniazid/rifampicin

    Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis.[2] It is a fixed dose combination of isoniazid and rifampicin (rifampin).[2] It is used together with other antituberculosis medication.[2] It is taken by mouth.[2]

    Side effects are those of the underlying medications.[2] Common side effects include poor coordination, poor appetite, nausea, numbness, and feeling tired.[3] More severe side effects include liver problems.[3] Use is generally not recommended in children.[2] It is unclear if use is safe in pregnancy.[4]

    It is on the World Health Organization's List of Essential Medicines.[5] The wholesale cost in the developing world is about US$5.10 a month.[6] In the United Kingdom a month of medication costs the NHS about 28.11 pounds.[7]

    Dosage

    The defined daily dose is not established.[1]

    References

    1. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 2 August 2020. Retrieved 18 September 2020.
    2. 1 2 3 4 5 6 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 142. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
    3. 1 2 "Isoniazid/rifampin Side Effects in Detail - Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
    4. ↑ "Isoniazid / rifampin Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 21 December 2016. Retrieved 18 December 2016.
    5. ↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    6. ↑ "Rifampicin + Isoniazid". International Drug Price Indicator Guide. Archived from the original on 22 January 2018. Retrieved 8 December 2016.
    7. ↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
    Identifiers:
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