Transduction (physiology)

Principal steps of sensory processing.

In physiology, sensory transduction is the conversion of a sensory stimulus from one form to another. Transduction in the nervous system typically refers to stimulus-alerting events wherein a physical stimulus is converted into an action potential, which is transmitted along axons towards the central nervous system for integration.[1] It is a step in the larger process of sensory processing.

A receptor cell converts the energy in a stimulus into an electrical signal.[1] Receptors are broadly split into two main categories: exteroceptors, which receive external sensory stimuli, and interoceptors, which receive internal sensory stimuli.[2][3]

Transduction and the senses

The visual system

In the visual system, sensory cells called rod and cone cells in the retina convert the physical energy of light signals into electrical impulses that travel to the brain. The light causes a conformational change in a protein called rhodopsin.[1] This conformational change sets in motion a series of molecular events that result in a reduction of the electrochemical gradient of the photoreceptor.[1] The decrease in the electrochemical gradient causes a reduction in the electrical signals going to the brain. Thus, in this example, more light hitting the photoreceptor results in the transduction of a signal into fewer electrical impulses, effectively communicating that stimulus to the brain. A change in neurotransmitter release is mediated through a second messenger system. Note that the change in neurotransmitter release is by rods. Because of the change, a change in light intensity causes the response of the rods to be much slower than expected (for a process associated with the nervous system).[4]

The auditory system

In the auditory system, sound vibrations (mechanical energy) are transduced into electrical energy by hair cells in the inner ear. Sound vibrations from an object cause vibrations in air molecules, which in turn, vibrate the ear drum. The movement of the eardrum causes the bones of the middle ear (the ossicles) to vibrate.[5][6] These vibrations then pass into the cochlea, the organ of hearing. Within the cochlea, the hair cells on the sensory epithelium of the organ of Corti bend and cause movement of the basilar membrane. The membrane undulates in different sized waves according to the frequency of the sound. Hair cells are then able to convert this movement (mechanical energy) into electrical signals (graded receptor potentials) which travel along auditory nerves to hearing centres in the brain.[7]

The olfactory system

In the olfactory system, odorant molecules in the mucus bind to G-protein receptors on olfactory cells. The G-protein activates a downstream signalling cascade that causes increased level of cyclic-AMP (cAMP), which trigger neurotransmitter release.[8]

The gustatory system

In the gustatory system, perception of five primary taste qualities (sweet, salty, sour, bitter and umami [savoriness] ) depends on taste transduction pathways, through taste receptor cells, G proteins, ion channels, and effector enzymes.[9]

The somatosensory system

In the somatosensory system the sensory transduction mainly involves the conversion of the mechanical signal such as pressure, skin compression, stretch, vibration to electro-ionic impulses through the process of mechanotransduction.[10] It also includes the sensory transduction related to thermoception and nociception.

References

  1. 1 2 3 4 Molecular cell biology. Lodish, Harvey F. (4th ed.). New York: W.H. Freeman. 2000. ISBN 0-7167-3136-3. OCLC 41266312.{{cite book}}: CS1 maint: others (link)
  2. ↑ "Definition of EXTEROCEPTOR". www.merriam-webster.com. Retrieved 2018-03-29.
  3. ↑ "Definition of INTEROCEPTOR". www.merriam-webster.com. Retrieved 2018-03-29.
  4. ↑ Silverthorn, Dee Unglaub. Human Physiology: An Integrated Approach, 3rd Edition, Inc, San Francisco, CA, 2004.
  5. ↑ Koike, Takuji; Wada, Hiroshi; Kobayashi, Toshimitsu (2002). "Modeling of the human middle ear using the finite-element method". The Journal of the Acoustical Society of America. 111 (3): 1306–1317. Bibcode:2002ASAJ..111.1306K. doi:10.1121/1.1451073. PMID 11931308.
  6. ↑ W., Clark, William (2008). Anatomy and physiology of hearing for audiologists. Ohlemiller, Kevin K. Clifton Park, NY: Thomson Delmar. ISBN 978-1-4018-1444-1. OCLC 123956006.
  7. ↑ Eatock, R. (2010). Auditory receptors and transduction. In E. Goldstein (Ed.), Encyclopedia of perception. (pp. 184-187). Thousand Oaks, CA: SAGE Publications, Inc. doi:10.4135/9781412972000.n63
  8. ↑ Ronnett, Gabriele V.; Moon, Cheil. L (2002). "G Proteins and Olfactory Signal Transduction". Annual Review of Physiology. 64 (1): 189–222. doi:10.1146/annurev.physiol.64.082701.102219. PMID 11826268.
  9. ↑ Timothy A Gilbertson; Sami Damak; Robert F Margolskee, "The molecular physiology of taste transduction", Current Opinion in Neurobiology (August 2000), 10 (4), pg. 519-527
  10. ↑ Biswas, Abhijit; Manivannan, M.; Srinivasan, Mandyam A. (2015). "Vibrotactile Sensitivity Threshold: Nonlinear Stochastic Mechanotransduction Model of the Pacinian Corpuscle". IEEE Transactions on Haptics. 8 (1): 102–113. doi:10.1109/TOH.2014.2369422. PMID 25398183. S2CID 15326972.
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