Agnosia

Agnosia
Image of a question mark in a speech bubble.
Agnosia causes loss of the ability to recognize or comprehend the meaning of objects even with intact senses.
SpecialtyPsychiatry, Neurology, Neuropsychology
Picture of the ventral and dorsal streams. The ventral stream is depicted in purple and the dorsal stream is depicted in green.

Agnosia is the inability to process sensory information. Often there is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss.[1] It is usually associated with brain injury or neurological illness, particularly after damage to the occipitotemporal border, which is part of the ventral stream.[2] Agnosia only affects a single modality,[3] such as vision or hearing.[4] More recently, a top-down interruption is considered to cause the disturbance of handling perceptual information.[5]

Types

NameDescription
AkinetopsiaAlso known as cerebral akinetopsia, this is associated with the inability to perceive visual motion. One cause of cerebral akinetopsia is lesions outside the striate cortex.[6]
AllotopagnosiaPatients cannot point at external targets located outside their own body, whether other persons' body parts or objects, but they perfectly point at their own body parts.
AnosognosiaThis is the inability to gain feedback about one's own condition and can be confused with lack of insight but is caused by problems in the feedback mechanisms in the brain. It is caused by neurological damage and can occur in connection with a range of neurological impairments but is most commonly referred to in cases of paralysis following stroke. Those with anosognosia with multiple impairments may even be aware of some of their impairments but completely unable to perceive others.
Apperceptive visual agnosiaPatients are unable to distinguish visual shapes and so have trouble recognizing, copying, or discriminating between different visual stimuli. Unlike patients suffering from associative agnosia, those with apperceptive agnosia are unable to copy images.[7]
Associative visual agnosiaPatients can describe visual scenes and classes of objects but still fail to recognize them. They may, for example, know that a fork is something you eat with but may mistake it for a spoon. Patients suffering from associative agnosia are still able to reproduce an image through copying.
AstereognosisAlso known as somatosensory agnosia, it is connected to tactile sense—that is, touch. Patient finds it difficult to recognize objects by touch based on its texture, size and weight. However, they may be able to describe it verbally or recognize same kind of objects from pictures or draw pictures of them. Thought to be connected to lesions or damage in somatosensory cortex.
Auditory agnosiaAuditory agnosia has been recognized since 1877.[8] With auditory agnosia, there is difficulty distinguishing environmental and non-verbal auditory cues including difficulty distinguishing speech from non-speech sounds even though hearing is usually normal. There are two types of auditory agnosia: semantic associative and discriminative agnosia. Semantic associative agnosia is associated with lesions to the left hemisphere, whereas discriminative agnosia is associated with lesions to the right hemisphere.[9]
Auditory verbal agnosiaAlso known as pure word deafness (PWD). This presents as a form of meaning 'deafness' in which hearing is intact but there is significant difficulty recognising spoken words as semantically meaningful.
AutotopagnosiaIs associated with the inability to orient parts of the body, and is often caused by a lesion in the parietal part of the posterior thalmic radiations.
Cerebral achromatopsiaA difficulty in perceiving colors in which the world may appear drab or in shades of gray. Cerebral achromatopsia is caused by neurological damage.[10][11] There are two regions of the brain which specialize for color recognition, areas V4 and V8. If there is a unilateral lesion to area V4, a loss of color perception in only half of the visual field may result known as hemiachromatopsia.[3] Similar, but distinct, is color agnosia, which involves having difficulty recognizing colors, while still being able to perceive them as measured by a color matching or categorizing task.[12]
Cortical deafnessRefers to people who do not perceive any auditory information but whose hearing is intact.
Environmental agnosiaIt is the inability to locate a specific room or building that one is familiar with, as well as the inability to provide directions for how to arrive at a particular location. These individuals experience difficulty with learning routes. This form of agnosia is often associated with lesions to the bilateral or right hemisphere posterior regions. It is also associated with prosopagnosia and Parkinson's disease.[3]
Finger agnosiaIs the inability to distinguish the fingers on the hand. It is present in lesions of the dominant parietal lobe, and is a component of Gerstmann syndrome.
Form agnosiaPatients perceive only parts of details, not the whole object.
HeterotopagnosiaPatients cannot point at another person's body parts, but can point at their own body parts.
Integrative agnosiaUsually a patient has a form of associative agnosia or apperceptive agnosia. However, in the case of integrative agnosia a patient falls in between a form of associative and apperceptive agnosia. This is where one has the ability to recognize elements of something but yet be unable to integrate these elements together into comprehensible perceptual wholes.
Pain agnosiaAlso referred to as congenital analgesia, this is the difficulty perceiving and processing pain; thought to underpin some forms of self injury.
PhonagnosiaIs the inability to recognize familiar voices, even though the hearer can understand the words used.[13]
ProsopagnosiaAlso known as faceblindness and facial agnosia: Patients cannot consciously recognize familiar faces, sometimes even including their own. This is often misperceived as an inability to remember names.
Pure alexiaInability to recognize text. Patients with pure alexia often have damage to their corpus callosum, as well as damage to the left visual association areas.[3] Pure alexia involves not being able to read printed material, but these individuals still have the ability to write. Individuals with pure alexia usually read words letter by letter.[14] However, individuals with pure alexia show a frequency effect. They are able to read high frequency words better and faster than they can read low frequency words.[15]
Semantic agnosiaThose with this form of agnosia are effectively 'object blind' until they use non-visual sensory systems to recognise the object. For example, feeling, tapping, smelling, rocking or flicking the object, may trigger realisation of its semantics (meaning).[16]
Social-emotional agnosiaSometimes referred to as expressive agnosia, this is a form of agnosia in which the person is unable to perceive facial expression, body language and intonation, rendering them unable to non-verbally perceive people's emotions and limiting that aspect of social interaction.
SimultagnosiaThe inability to process visual input as a whole. The person instead processes faces, bodies, objects, rooms, places, pictures in a bit-by-bit fashion.[17] When looking at a picture they can describe the parts of the picture but struggle to comprehend the picture as a whole. Simultagnosia occurs in Bálint syndrome[18] but may also occur in brain injury. This condition can also be described by only seeing one object at a time. An example is having two cups in your visual field and only being able to see one at a time.
Tactile agnosiaImpaired ability to recognize or identify objects by touch alone.[19]
Topographical disorientationAlso known as topographical agnosia or topographagnosia, this is a form of visual agnosia in which a person cannot rely on visual cues to guide them directionally due to the inability to recognize objects. Nevertheless, they may still have an excellent capacity to describe the visual layout of the same place. Patients with topographical agnosia have the ability to read maps, but become lost in familiar environments.[20]
Visuospatial dysgnosiaThis is a loss of the sense of "whereness" in the relation of oneself to one's environment and in the relation of objects to each other. It may include constructional apraxia, topographical disorientation, optic ataxia, ocular motor apraxia, dressing apraxia, and right-left confusion.
Visual agnosiaIs associated with lesions of the left occipital lobe and temporal lobes. Many types of visual agnosia involve the inability to recognize objects.[21]

Visual agnosia

Visual agnosia is a broad category that refers to a deficiency in the ability to recognize visual objects. Visual agnosia can be further subdivided into two different subtypes: apperceptive visual agnosia and associative visual agnosia.[22]

Individuals with apperceptive visual agnosia display the ability to see contours and outlines when shown an object, but they experience difficulty if asked to categorize objects. Apperceptive visual agnosia is associated with damage to one hemisphere, specifically damage to the posterior sections of the right hemisphere.[22]

In contrast, individuals with associative visual agnosia experience difficulty when asked to name objects. Associative agnosia is associated with damage to both the right and left hemispheres at the occipitotemporal border.[22] A specific form of associative visual agnosia is known as prosopagnosia. Prosopagnosia is the inability to recognize faces. For example, these individuals have difficulty recognizing friends, family and coworkers.[22] However, individuals with prosopagnosia can recognize all other types of visual stimuli.[23]

Speech agnosia

Speech agnosia, or auditory verbal agnosia, refers to "an inability to comprehend spoken words despite intact hearing, speech production and reading ability".[24] Patients report that they do indeed hear sounds being produced, but that the sounds are fundamentally unrecognizable/untranslatable.

  1. EXAMINER: What did you eat for breakfast?
  2. PATIENT: Breakfast, breakfast, it sounds familiar but it doesn't speak to me. (Obler & Gjerlow 1999:45)

Despite an inability to process what the speaker is saying, some patients have been reported to recognize certain characteristic information about the speaker's voice (such as being a man or woman).[24]

Causes

Agnosia can result from strokes, dementia, or other neurological disorders. It may also be trauma-induced by a head injury, brain infection, or hereditary. Additionally, some forms of agnosia may be the result of developmental disorders.[4] Damage causing agnosia usually occurs in either the occipital or parietal lobes of the brain. Although one modality may be affected, cognitive abilities in other areas are preserved.[4]

Patients who experience dramatic recovery from blindness experience significant to total agnosia.[25]

The effect of damage to the superior temporal sulcus is consistent with several types of neurolinguistic deficiencies, and some contend that agnosia is one of them. The superior temporal sulcus is vital for speech comprehension because the region is highly involved with the lexical interface. According to the 1985 TRACE II Model, the lexical interface associates sound waves (phonemes) with morphological features to produce meaningful words. This association process is accomplished by lateral inhibition/excitement of certain words within an individual's lexicon (vocabulary).[24] For instance, if an experimenter were to say DOG aloud, the utterance would activate and inhibit various words within the subjects lexical interface:

  • DOG activates 3, and inhibits 0 letters in DOG. – +3
  • DOG activates 2, and inhibits 1 letters in FOG. – +2
  • DOG activates 1, and inhibits 2 letters in DAN. – +1

The consistency of this model to agnosia is shown by evidence that bilateral lesions to the superior temporal sulcus produces 'pure word deafness' (Kussmaul, 1877), or as it is understood today, speech agnosia. Patients with pure word deafness demonstrate the inability to recognize and process speech sounds with normal auditory processing for non-speech sounds below the level of the cortex.[24]

Diagnosis

In order to assess an individual for agnosia, it must be verified that the individual is not suffering from a loss of sensation, and that both their language abilities and intelligence are intact. In order for an individual to be diagnosed with agnosia, they must only be experiencing a sensory deficit in a single modality. To make a diagnosis, the distinction between apperceptive and associative agnosia must be made. This distinction can be made by having the individual complete copying and matching tasks. If the individual is suffering from a form of apperceptive agnosia they will not be able to match two stimuli that are identical in appearance. In contrast, if an individual is suffering from a form of associative agnosia, they will not be able to match different examples of a stimulus. For example, an individual who has been diagnosed with associative agnosia in the visual modality would not be able to match pictures of a laptop that is open with a laptop that is closed.[3]

Pure alexia

Individuals with pure alexia usually have difficulty reading words as well as difficulty with identifying letters. In order to assess whether an individual has pure alexia, tests of copying and recognition must be performed. An individual with pure alexia should be able to copy a set of words, and should be able to recognize letters.[3]

Prosopagnosia

Individuals are usually shown pictures of human faces that may be familiar to them such as famous actors, singers, politicians or family members. The pictures shown to the patient are selected to be age and culture appropriate. The task involves the examiner asking the individual to name each face. If the individual cannot name whose face appears in the picture, the examiner may ask a question that would help to recognize the face in the picture.[3]

Treatment

For all practical purposes, there is no direct cure. Patients may improve if information is presented in other modalities than the damaged one. Different types of therapies can help to reverse the effects of agnosia. In some cases, occupational therapy or speech therapy can improve agnosia, depending on its cause.

Initially many individuals with a form of agnosia are unaware of the extent to which they have either a perceptual or recognition deficit. This may be caused by anosognosia which is the lack of awareness of a deficit. This lack of awareness usually leads to a form of denial and resistance to any form of help or treatment. There are various methods that can be used which can help the individual recognize the impairment in perception or recognition that they may have. A patient can be presented with a stimulus to the impaired modality only to help increase their awareness of their deficit. Alternatively, a task can be broken down into its component parts so that the individual can see each part of the problem caused by the deficit. Once the individual acknowledges their perceptual or recognition deficit, a form of treatment may be recommended. There are various forms of treatment such as compensatory strategies with alternate modalities, verbal strategies, alternate cues and organizational strategies.[3]

Verbal strategies

Using verbal descriptions may be helpful for individuals with certain types of agnosia. Individuals such as prosopagnosics may find it useful to listen to a description of their friend or family member and recognize them based on this description more easily than through visual cues.[3]

Alternate cues

Alternate cues may be particularly useful to an individual with environmental agnosia or prosopagnosia. Alternate cues for an individual with environmental agnosia may include color cues or tactile markers to symbolize a new room or to remember an area by. Prosopagnosics may use alternate cues such as a scar on an individual's face or crooked teeth in order to recognize the individual.[3] Hair color and length can be helpful cues as well.[5]

Organizational strategies

Organizational strategies may be extremely helpful for an individual with visual agnosia. For example, organizing clothes according to different hangers provides tactile cues for the individual, making it easier to identify certain forms of clothing as opposed to relying solely on visual cues.[3]

Alternative medicine

These strategies elicit the use of an unaffected modality. For example, visual agnosics can use tactile information in replacement of visual information. Alternatively, an individual with prosopagnosia can use auditory information in order to replace visual information. For example, an individual with prosopagnosia can wait for someone to speak, and will usually recognize the individual from their speech.[3]

Current research

There are clinical trials being done to further research for treatments. At the National Institute of Neurological Disorders and Stroke (NINDS) they support research for rare diseases like agnosia.[4] Some organizations that are recruiting for trials are using clincaltrials.gov and give status updates on the trials.[26]

History

The term 'agnosia' comes from the Ancient Greek ἀγνωσία (agnosia), "ignorance", "absence of knowledge". It was introduced by Sigmund Freud in 1891:[27] "For disturbances in the recognition of objects, which Finkelnburg classes as asymbolia, I should like to propose the term 'agnosia'." Prior to Freud's introduction of the term, some of the first ideas about agnosia came from Carl Wernicke, who created theories about receptive aphasia in 1874. He noted that individuals with receptive aphasia did not possess the ability to understand speech or repeat words. He believed that receptive aphasia was due to lesions of the posterior third of the left superior temporal gyrus. Due to these lesions, Wernicke believed that individuals with receptive aphasia had a limited deafness for certain sounds and frequencies in speech.[8]

After Wernicke, came Kussmaul in 1877 who attempted to explain why auditory verbal agnosia, also known as word deafness, occurs. Contrary to Wernicke's explanations, Kussmaul believed auditory verbal agnosia was the result of major destruction to the first left temporal gyrus. Kussmaul also posited about the origins of alexia (acquired dyslexia) also known as word blindness. He believed that word blindness was the result of lesions to the left angular and supramarginal gyri.[8]

Heinrich Lissauer shared his ideas about agnosia after Wernicke and Kussmaul.[8] In 1890, he theorized that there were two ways in which object recognition impairment could occur. One way in which impairment could occur was if there was damage to early perceptual processing or if there was damage to the actual object representation. If the actual object representation was damaged, this would not allow the object to be stored in visual memory, and therefore the individual would not be able to recognize the object.[28] During the time of Wernicke, Kussmaul and Lissauer there was little known about the cerebral cortex. Today, with new neuroimaging techniques, we have been able to expand our knowledge on agnosia greatly.[3]

References

  1. ↑ "AGNOSIA".
  2. ↑ Kolb, Bryan; Whishaw, Ian Q. (3 March 2003). Fundamentals of Human Neuropsychology. Worth Publishers. ISBN 978-0-7167-5300-1.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 Burns, MS (2004). "Clinical management of agnosia". Top Stroke Rehabil. 11 (1): 1–9. doi:10.1310/N13K-YKYQ-3XX1-NFAV. PMID 14872395. S2CID 5758683. Archived from the original on 2013-01-28.
  4. 1 2 3 4 "NINDS Agnosia Information Page". National Institute of Neurological Disorders and Stroke. Archived from the original on 2013-01-27. Retrieved 2012-03-28.
  5. 1 2 "Agnosia". Archived from the original on 2017-05-26. Retrieved 2016-12-16.
  6. ↑ Zeki, S (1991). "Cerebral akinetopsia (visual motion blindness)". Brain. 114 (2): 811–824. doi:10.1093/brain/114.2.811. PMID 2043951.
  7. ↑ Riddoch MJ, Humphreys GW (May 2003). "Visual agnosia". Neurol Clin. 21 (2): 501–20. doi:10.1016/s0733-8619(02)00095-6. PMID 12916489.
  8. 1 2 3 4 Goldstein, Marvin N. (1974). "Auditory agnosia for speech ("pure word-deafness")". Brain and Language. 1 (2): 195–204. doi:10.1016/0093-934X(74)90034-0. ISSN 0093-934X.
  9. ↑ Vignolo, L. A (1982). "Auditory Agnosia". Biological Sciences. 298 (1089): 49–57. Bibcode:1982RSPTB.298...49V. doi:10.1098/rstb.1982.0071. PMID 6125975.
  10. ↑ Cowey A, Alexander I, Heywood C, Kentridge R (August 2008). "Pupillary responses to coloured and contourless displays in total cerebral achromatopsia". Brain. 131 (Pt 8): 2153–60. doi:10.1093/brain/awn110. PMID 18550620.
  11. ↑ Woodward, T. S; M. J Dixon; K. T Mullen; K. M Christensen; D. N. Bub (1999). "Analysis of errors in color agnosia: A single case study". Neurocase. 5 (2): 95–108. doi:10.1093/neucas/5.2.95.
  12. ↑ Zeki S (1990). "A century of cerebral achromatopsia". Brain. 113 (Pt 6): 1721–77. doi:10.1093/brain/113.6.1721. PMID 2276043.
  13. ↑ Van Lancker DR, Cummings JL, Kreiman J, Dobkin BH (June 1988). "Phonagnosia: a dissociation between familiar and unfamiliar voices". Cortex. 24 (2): 195–209. doi:10.1016/s0010-9452(88)80029-7. PMID 3416603. S2CID 28617313.
  14. ↑ Cherney LR (2004). "Aphasia, alexia, and oral reading". Top Stroke Rehabil. 11 (1): 22–36. doi:10.1310/VUPX-WDX7-J1EU-00TB. PMID 14872397.
  15. ↑ Sakurai, Y (2004). "Varieties of alexia from fusiform, posterior inferior temporal and posterior occipital gyrus". Behavioural Neurology. 15 (1–2): 35–50. doi:10.1155/2004/305194. PMC 5488613. PMID 15201492.
  16. ↑ Magnié MN, Ferreira CT, Giusiano B, Poncet M (January 1999). "Category specificity in object agnosia: preservation of sensorimotor experiences related to objects". Neuropsychologia. 37 (1): 67–74. doi:10.1016/S0028-3932(98)00045-1. PMID 9920472. S2CID 1550842.
  17. ↑ Coslett HB, Saffran E (August 1991). "Simultanagnosia. To see but not two see". Brain. 114 (4): 1523–45. doi:10.1093/brain/114.4.1523. PMID 1884165.
  18. ↑ Rizzo M, Vecera SP (February 2002). "Psychoanatomical substrates of Bálint's syndrome". J. Neurol. Neurosurg. Psychiatry. 72 (2): 162–78. doi:10.1136/jnnp.72.2.162. PMC 1737727. PMID 11796765.
  19. ↑ Reed CL, Caselli RJ, Farah MJ (June 1996). "Tactile agnosia. Underlying impairment and implications for normal tactile object recognition". Brain. 119 (3): 875–88. doi:10.1093/brain/119.3.875. PMID 8673499.
  20. ↑ Mendez, Mario F; Cherrier, Monique M (2003). "Agnosia for scenes in topographagnosia". Neuropsychologia. 41 (10): 1387–1395. doi:10.1016/S0028-3932(03)00041-1. PMID 12757910. S2CID 9021982.
  21. ↑ Greene JD (December 2005). "Apraxia, agnosias, and higher visual function abnormalities". J. Neurol. Neurosurg. Psychiatry. 76 (Suppl 5): v25–34. doi:10.1136/jnnp.2005.081885. PMC 1765708. PMID 16291919.
  22. 1 2 3 4 al.], Kathleen M. Galotti … [et (2010). Cognitive psychology : in and out of the laboratory (1st Canadian ed.). Canada: Nelson. ISBN 978-0-17-644065-7.
  23. ↑ Silverman, Jay Friedenberg, Gordon (2011-07-14). Cognitive science : an introduction to the study of mind (2nd ed.). Thousand Oaks, Calif.: SAGE. ISBN 978-1-4129-7761-6.
  24. 1 2 3 4 Howard, Harry. "The superior temporal sulcus". Brain and Language. Archived from the original on 22 December 2015. Retrieved 6 December 2015.
  25. ↑ "The New Yorker: From the Archives: Content". Archived from the original on 2006-08-31. Retrieved 2010-05-05. mentally blind, or agnosic—able to see but not to decipher what he was seeing.
  26. ↑ "ClinicalTrials.gov".
  27. ↑ "Freud 1891">Freud, Sigmund, Zur Auffassung der Aphasien, Vienna, 1891, p. 80
  28. ↑ Vecera, P. S; Gilds, S. K (1998). "What processing is impaired in appreceptive agnosia? Evidence from normal subjects". Journal of Cognitive Neuroscience. 10 (5): 568–580. doi:10.1162/089892998562979. PMID 9802990. S2CID 21568462.
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