Benzylpenicilloyl polylysine

Benzylpenicilloyl polylysine
Clinical data
Trade namesPre-Pen
Other namesPre-Pen
License data
Routes of
administration		Liquid intradermal
ATC code
  • none
Legal status
Legal status
Identifiers
IUPAC name
  • [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate : L-Lysine homopolymer
CAS Number
DrugBank
ChemSpider
  • none
UNII
ChEMBL
CompTox Dashboard (EPA)
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Benzylpenicilloyl polylysine (Pre-Pen) is used as a skin test before the administration of penicillin. It is used to detect the immunoglobulin E antibodies.[1][2] The chemical structure consists of the benzylpenicilloyl group attached to a polymer of L-lysine.[3][4][5]

References

  1. ↑ "Benzylpenicilloyl polylysine". PharmGKB.
  2. ↑ "Benzylpenicilloyl polylysine". DrugBank.
  3. ↑ Vemuri P, Harris KE, Suh LA, Grammer LC (2004). "Preparation of benzylpenicilloyl-polylysine: a preliminary study". Allergy and Asthma Proceedings. 25 (3): 165–168. PMID 15317320.
  4. ↑ Goldschmidt BM, Levine BB (June 1983). "The preparation and determination of structure of benzylpenicilloyl compounds used in skin-testing for penicillin allergy". The Journal of Antibiotics. 36 (6): 709–14. doi:10.7164/antibiotics.36.709. PMID 6874593.
  5. ↑ "PRE-PEN® (benzylpenicilloyl polylysine injection USP) Skin Test Antigen". DailyMed. U.S. National Library of Medicine.
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