T-lymphoblastic leukemia/lymphoma

T-lymphoblastic leukemia/lymphoma
Other names: Precursor T-cell lymphoblastic lymphoma, Precursor T acute lymphoblastic leukemia/lymphoma
a-c) Supraclavicular lymph node biopsy
SpecialtyHematology, oncology

T-lymphoblastic leukemia/lymphoma (WHO 2008),[1]: 219  previously labeled precursor T-lymphoblastic leukemia/lymphoma (WHO 2001)[1]: 219  is a form of lymphoid leukemia[2][3] and lymphoma[4] in which too many T-cell lymphoblasts (immature white blood cells) are found in the blood, bone marrow, and tissues, particularly mediastinal lymph nodes.[1]: 635  Labeling as leukemia or lymphoma depends on which feature is more pronounced in a given situation, but has no biological or treatment implication.[1]: 635 

It is uncommon in adults, but represents 15% of childhood acute lymphoblastic leukemia and 90% of lymphoblastic lymphoma.[1]: 635 

The 2008 terminology dropped "precursor" to avoid linguistic redundancy because the lymphoblast is an immature precursor cell by definition.[1]: 219 

References

  1. 1 2 3 4 5 6 Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber, DA (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406.
  2. ↑ Kim MA, Lee GW, Maeng KY (August 2005). "An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma". Ann. Hematol. 84 (8): 553–4. doi:10.1007/s00277-005-1042-4. PMID 15843931. S2CID 40149515.
  3. ↑ Lyman MD, Neuhauser TS (April 2002). "Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix". Ann Diagn Pathol. 6 (2): 125–8. doi:10.1053/adpa.2002.32381. PMID 12004362.
  4. ↑ Han X, Bueso-Ramos CE (April 2007). "Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. 127 (4): 528–44. doi:10.1309/2QE3A6EKQ8UYDYRC. PMID 17369128.

 This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".

Classification


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