GemOx

GemOx or GEMOX is an acronym for one of the chemotherapy regimens used in the treatment of relapsed or primary refractory non-Hodgkin's lymphoma and Hodgkin's lymphoma.

When combined with Rituximab it is called R-GemOx, R-GEMOX or GemOx-R, GEMOX-R.

The [R]-GemOx regimen consists of:

  1. (R)ituximab - anti-CD20 monoclonal antibody that has the ability to kill both normal and malignant B cells;
  2. (Gem)citabine - an antimetabolite;
  3. (Ox)aliplatin - a platinum-based alkylating antineoplastic agent.[1][2]

Dosing regimen

DrugDoseModeDays
(R)ituximab375 mg/m2IV infusionDay 1
(Gem)citabine1000 mg/m2IV infusion in 500 ml normal saline with the speed of 10 mg/m2/minDay 2
(Ox)aliplatin100 mg/m2IV infusion over 2hrsDay 2

References

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