Tezacaftor/ivacaftor

Tezacaftor/ivacaftor
Combination of
TezacaftorCFTR corrector
IvacaftorCFTR potentiator
Names
Trade namesSymkevi, Symdeko
Clinical data
Main usesCystic fibrosis[1]
Side effectsNausea, headache, diarrhea, dizziness[1]
InteractionsCYP3A inhibitors[2]
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Pregnancy
category
  • AU: B3
    External links
    AHFS/Drugs.comMonograph

    Tezacaftor/ivacaftor, sold under the brand name Symdeko, is a combination medication of tezacaftor and ivacaftor used to treat cystic fibrosis.[1] It is only used in people with specific mutations.[1] It is taken by mouth.[1]

    Common side effects include nausea, headache, diarrhea, and dizziness.[1] Other side effects may include liver problems and cataracts.[1][3] In those with significant liver problems a lower dose may be required.[3] Tezacaftor increases the number of CFTR while ivacaftor increases the ability of CFTR.[2]

    The combination was approved for medical use in the United States and Europe in 2018.[3][2] In the United States it costs about 304,000 USD per year as of 2021.[4] It became available in the United Kingdom in 2020 at a cost of about £82,000 per year.[5]

    Medical use

    It may be used in people over the age of 5.[2]

    Dosage

    A combination tablet of tezacaftor 100 mg with ivacaftor 150 mg is taken in the am while a ivacaftor 150 mg tablet is taken in the evening.[3]

    References

    1. 1 2 3 4 5 6 7 "Tezacaftor and Ivacaftor Monograph for Professionals". Drugs.com. Archived from the original on 27 February 2021. Retrieved 8 October 2021.
    2. 1 2 3 4 "Symkevi". Archived from the original on 8 January 2021. Retrieved 8 October 2021.
    3. 1 2 3 4 "SYMDEKO™ (tezacaftor/ivacaftor) tablets; (ivacaftor) tablets, for oral use" (PDF). Archived (PDF) from the original on 9 June 2021. Retrieved 8 October 2021.
    4. ↑ "Symdeko Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 11 November 2020. Retrieved 8 October 2021.
    5. ↑ "Tezacaftor + ivacaftor". SPS - Specialist Pharmacy Service. 29 December 2015. Archived from the original on 26 February 2021. Retrieved 8 October 2021.
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