Atenolol/chlorthalidone

Atenolol/chlorthalidone
Combination of
AtenololBeta blocker
ChlortalidoneDiuretic
Names
Trade namesTenoretic, Tenoret, others
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Routes of
use		By mouth
Defined daily dosenot established[1]
External links
AHFS/Drugs.comFDA Professional Drug Information
Legal
License data
Legal status

Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure.[3][4] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic.[5] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually.[6] It is taken by mouth.[3]

Common side effects include gastrointestinal upset and gout.[4] Serious side effects may include liver problems, pancreatitis, and psychosis.[4] Use is not recommended during pregnancy.[4] Use during breastfeeding may harm the baby.[3] Atenolol works by blocking β1-adrenergic receptors in the heart, thus decreasing the heart rate and workload.[4] Chlorthalidone works by increasing the amount of sodium lost by the kidneys.[3]

The combination was approved for medical use in the United States in 1984.[5] It is available as a generic medication.[4] A month supply in the United Kingdom costs the NHS less than 2 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$12.30.[7] In 2017, it was the 295th most commonly prescribed medication in the United States, with more than one million prescriptions.[8][9]

Dosage

The defined daily dose is not established.[1]

Society and culture

Cost

A month supply in the United Kingdom costs the NHS less than 2 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$12.30.[7] In 2017, it was the 295th most commonly prescribed medication in the United States, with more than one million prescriptions.[10][11]

  • AtenololChlorthalidone costs (USA)
    AtenololChlorthalidone costs (USA)
  • AtenololChlorthalidone prescriptions (USA)
    AtenololChlorthalidone prescriptions (USA)

References

  1. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 9 September 2020.
  2. ↑ "Tenoret 50 mg/12.5 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 29 November 2019. Archived from the original on 22 September 2020. Retrieved 4 May 2020.
  3. 1 2 3 4 "DailyMed - atenolol and chlorthalidone tablet". dailymed.nlm.nih.gov. Archived from the original on 18 September 2015. Retrieved 18 April 2019.
  4. 1 2 3 4 5 6 7 8 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 153. ISBN 9780857113382.
  5. 1 2 "Atenolol and Chlorthalidone Tablets - FDA prescribing information, side effects and uses". Drugs.com. Archived from the original on 18 April 2019. Retrieved 18 April 2019.
  6. ↑ "Atenolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 18 April 2019. Retrieved 18 April 2019.
  7. 1 2 "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  8. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  9. ↑ "Atenolol; Chlorthalidone - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
  10. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  11. ↑ "Atenolol; Chlorthalidone - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
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