Facet cell

Facet cells (also known as umbrella cells,[1] capping cells, superficial urotheliocytes) are a type of cells located in the renal pelvis, the ureters,and the urethra. Umbrella cells form the outermost layer of the urothelium, which is a special type of epithelium found in the renal pelvis, the ureters, and the urethra. Umbrella cells are special in that they can contain multiple nuclei. Their apical membrane contains numerous invaginations, which allows the cells to stretch during urination. Umbrella cells are linked together with tight junctions which:

  • prevents urine from leaking through the epithelium.
  • creates an osmotic barrier. Urine osmolarity can range from 50 to 1200 mmol/L while the normal body osmolarity is 290 mmol/L. The difference between the two could lead to fluid entering or exiting the ureter due to the osmotic pressure.[2]

Umbrella cells contain uroplakin ia, uroplakin ib, uroplakin ii, and uroplakin iii.[3] These increase the strength of the urothelium.[3]

References

  1. ↑ Born, Martin; Pahner, Ingrid; Ahnert-Hilger, Gudrun; Jöns, Thomas (July 2003). "The maintenance of the permeability barrier of bladder facet cells requires a continuous fusion of discoid vesicles with the apical plasma membrane". European Journal of Cell Biology. 82 (7): 343–350. doi:10.1078/0171-9335-00326. PMID 12924629.
  2. ↑ Lüllman-Rauch (2008). Histologie 1er cycle des études médicales. De Boeck Supérieur. ISBN 9782804156923.
  3. 1 2 "Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder?". European Journal of Cell Biology. 84 (2–3): 393–405. 2005-03-09. doi:10.1016/j.ejcb.2004.12.011. ISSN 0171-9335.
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