Geriatrics

Geriatrics
An elderly woman in a residential care home receiving a birthday cake
Significant diseasesDementia, arthritis, palliative care, osteoporosis, osteoarthritis, rheumatoid arthritis, Parkinson's disease, atherosclerosis, heart disease, high blood pressure, high cholesterol
SpecialistGeriatrician
Geriatrician
Occupation
Names
  • Physician
Occupation type
Specialty
Activity sectors
Medicine
Specialty{{#statements:P1995}}
Description
Education required
Fields of
employment
Hospitals, Clinics

Geriatrics, or geriatric medicine,[1] is a specialty that focuses on health care of elderly people.[2] It aims to promote health by preventing and treating diseases and disabilities in older adults.[3] There is no set age at which patients may be under the care of a geriatrician, or geriatric physician, a physician who specializes in the care of elderly people. Rather, this decision is determined by the individual patient's needs and the availability of a specialist. It is important to note the difference between geriatrics, the care of aged people and gerontology, which is the study of the aging process itself. The term geriatrics comes from the Greek γέρων geron meaning "old man", and ιατρός iatros meaning "healer". However, geriatrics is sometimes called medical gerontology.

Scope

Elderly man at a nursing home in Norway

Differences between adult and geriatric medicine

Geriatrics differs from standard adult medicine because it focuses on the unique needs of the elderly person. The aged body is different physiologically from the younger adult body, and during old age, the decline of various organ systems becomes manifest. Previous health issues and lifestyle choices produce a different constellation of diseases and symptoms in different people. The appearance of symptoms depends on the remaining healthy reserves in the organs. Smokers, for example, consume their respiratory system reserve early and rapidly.[4]

Geriatricians distinguish between diseases and the effects of normal aging. For example, renal impairment may be a part of aging, but kidney failure and urinary incontinence are not. Geriatricians aim to treat diseases that are present and achieve healthy aging. Geriatricians focus on achieving the patient's highest priorities in the context of multiple chronic conditions, and on preserving function.

Increased complexity

The decline in physiological reserve in organs makes the elderly develop some kinds of diseases and have more complications from mild problems (such as dehydration from a mild gastroenteritis). Multiple problems may compound: A mild fever in elderly persons may cause confusion, which may lead to a fall and to a fracture of the neck of the femur ("broken hip").

Elderly people require specific attention to medications. Elderly people particularly are subjected to polypharmacy (taking multiple medications). Some elderly people have multiple medical disorders; some have self-prescribed many herbal medications and over-the-counter drugs. This polypharmacy may increase the risk of drug interactions or adverse drug reactions. In one study, it was found that prescription and nonprescription medications were commonly used together among older adults, with nearly 1 in 25 individuals potentially at risk for a major drug-drug interaction.[5] Drugs metabolites are excreted mostly by the kidneys or the liver, which may be impaired in the elderly, necessitating medication adjustment.

The presentation of disease in elderly persons may be vague and non-specific, or it may include delirium or falls. (Pneumonia, for example, may present with low-grade fever and confusion, rather than the high fever and cough seen in younger people.) Some elderly people may find it hard to describe their symptoms in words, especially if the disease is causing confusion, or if they have cognitive impairment. Delirium in the elderly may be caused by a minor problem such as constipation or by something as serious and life-threatening as a heart attack. Many of these problems are treatable, if the root cause can be discovered.

Geriatric giants

The so-called geriatric giants are the major categories of impairment that appear in elderly people, especially as they begin to fail. These include immobility, instability, incontinence and impaired intellect/memory.

Sarcopenia, the decline in muscle mass with age, is a significant contributor to fall risk, instability, immobility and disability in the geriatric population.[6]

Impaired vision and hearing loss are common chronic problems among older people. Hearing problems can lead to social isolation, depression,[7] and dependence as the person can no longer talk to other people, receive information over the telephone, or engage in simple transactions, such as talking to a person at a bank or store. Vision problems lead to falls from tripping over unseen objects, medicine being taken incorrectly because the written instructions could not be read,[8] and finances being mismanaged.

Practical concerns

Functional abilities, independence and quality of life issues are of great concern to geriatricians and their patients. Elderly people generally want to live independently as long as possible, which requires them to be able to engage in self-care and other activities of daily living. A geriatrician may be able to provide information about elder care options, and refers people to home care services, skilled nursing facilities, assisted living facilities, and hospice as appropriate.

Frail elderly people may choose to decline some kinds of medical care, because the risk-benefit ratio is different. For example, frail elderly women routinely stop screening mammograms, because breast cancer is typically a slowly growing disease that would cause them no pain, impairment, or loss of life before they would die of other causes. Frail people are also at significant risk of post-surgical complications and the need for extended care, and an accurate prediction—based on validated measures, rather than how old the patient's face looks—can help older patients make fully informed choices about their options. Assessment of older patients before elective surgeries can accurately predict the patients' recovery trajectories.[9] One frailty scale uses five items: unintentional weight loss, muscle weakness, exhaustion, low physical activity, and slowed walking speed. A healthy person scores 0; a very frail person scores 5. Compared to non-frail elderly people, people with intermediate frailty scores (2 or 3) are twice as likely to have post-surgical complications, spend 50% more time in the hospital, and are three times as likely to be discharged to a skilled nursing facility instead of to their own homes.[9] Frail elderly patients (score of 4 or 5) who were living at home before the surgery have even worse outcomes, with the risk of being discharged to a nursing home rising to twenty times the rate for non-frail elderly people.

Some diseases commonly seen in elderly are rare in adults, e.g., dementia, delirium, falls. As societies aged, many specialized geriatric- and geriatrics-related services emerged[10][11] including:

Medical

Surgical

  • Geriatric orthopaedics or orthogeriatrics (close cooperation with orthopedic surgery and a focus on osteoporosis and rehabilitation).
  • Geriatric cardiothoracic surgery
  • Geriatric urology
  • Geriatric otolaryngology
  • Geriatric general surgery
  • Geriatric trauma
  • Geriatric gynecology
  • Geriatric ophthalmology

Other geriatrics subspecialties

  • Geriatric anesthesia (focuses on anesthesia & perioperative care of elderly)
  • Geriatric intensive-care unit: (a special type of intensive care unit dedicated to critically ill elderly)
  • Geriatric nursing (focuses on nursing of elderly patients and the aged).
  • Geriatric nutrition
  • Geriatric occupational therapy
  • Geriatric pain management
  • Geriatric pharmacy
  • Geriatric optometry
  • Geriatric physical therapy
  • Geriatric podiatry
  • Geriatric psychology
  • Geriatric speech-language pathology (focuses on neurological disorders such as dysphagia, stroke, aphasia, and traumatic brain injury)
  • Geriatric mental health counselor/specialist (focuses on treatment more so than assessment)
  • Geriatric audiology

History

One of the eight branches of the traditional Indian system of medicine, Ayurveda, is jara or rasayana, similar to geriatrics. Charaka described the fatigue and physical exhaustion caused by premature aging as the result of a poor diet. The Charaka Samhita recommends that elderly patients avoid excessive physical or mental strain and consume a light but nutritious diet.[12]

A number of physicians in the Byzantine Empire studied geriatrics, with doctors like Aëtius of Amida evidently specializing in the field. Alexander of Tralles viewed the process of aging as a natural and inevitable form of marasmus, caused by the loss of moisture in body tissue. The works of Aëtius describe the mental and physical symptoms of aging. Theophilus Protospatharius and Joannes Actuarius also discussed the topic in their medical works. Byzantine physicians typically drew on the works of Oribasius and recommended that elderly patients consume a diet rich in foods that provide "heat and moisture". They also recommended frequent bathing, massaging, rest, and low-intensity exercise regimens.[13]

In The Canon of Medicine, written by Avicenna in 1025, the author was concerned with how "old folk need plenty of sleep" and how their bodies should be anointed with oil, and recommended exercises such as walking or horse-riding. Thesis III of the Canon discussed the diet suitable for old people, and dedicated several sections to elderly patients who become constipated.[14][15][16]

The Arab physician Algizar (circa 898–980) wrote a book on the medicine and health of the elderly.[17][18] He also wrote a book on sleep disorders and another one on forgetfulness and how to strengthen memory,[19][20][21] and a treatise on causes of mortality.[17] Another Arab physician in the 9th century, Ishaq ibn Hunayn (died 910), the son of Nestorian Christian scholar Hunayn Ibn Ishaq, wrote a Treatise on Drugs for Forgetfulness.[22]

George Day published the Diseases of Advanced Life in 1849, one of the first publications on the subject of geriatric medicine.[23] The first modern geriatric hospital was founded in Belgrade, Serbia, in 1881 by doctor Laza Lazarević.[24]

The term geriatrics was proposed in 1908 by Ilya Ilyich Mechnikov, Laurate of the Nobel Prize for Medicine and later by 1909 by Dr. Ignatz Leo Nascher,[25] former Chief of Clinic in the Mount Sinai Hospital Outpatient Department (New York City) and a "father" of geriatrics in the United States.[26]

Modern geriatrics in the United Kingdom began with the "mother"[27] of geriatrics, Dr. Marjory Warren.[23] Warren emphasized that rehabilitation was essential to the care of older people. Using her experiences as a physician in a London Workhouse infirmary, she believed that merely keeping older people fed until they died was not enough; they needed diagnosis, treatment, care, and support. She found that patients, some of whom had previously been bedridden, were able to gain some degree of independence with the correct assessment and treatment.

The practice of geriatrics in the UK is also one with a rich multidisciplinary history. It values all the professions, not just medicine, for their contributions in optimizing the well-being and independence of older people.

Another innovator of British geriatrics is Bernard Isaacs, who described the "giants" of geriatrics mentioned above: immobility and instability, incontinence, and impaired intellect.[28][29] Isaacs asserted that, if examined closely enough, all common problems with older people relate to one or more of these giants.

The care of older people in the UK has been advanced by the implementation of the National Service Frameworks for Older People, which outlines key areas for attention.[30]

Geriatrician training

United States

In the United States, geriatricians are primary-care physicians (D.O. or M.D.) who are board-certified in either family medicine or internal medicine and who have also acquired the additional training necessary to obtain the Certificate of Added Qualifications (CAQ) in geriatric medicine. Geriatricians have developed an expanded expertise in the aging process, the impact of aging on illness patterns, drug therapy in seniors, health maintenance, and rehabilitation. They serve in a variety of roles including hospital care, long-term care, home care, and terminal care. They are frequently involved in ethics consultations to represent the unique health and diseases patterns seen in seniors. The model of care practiced by geriatricians is heavily focused on working closely with other disciplines such as nurses, pharmacists, therapists, and social workers.

United Kingdom

In the United Kingdom, most geriatricians are hospital physicians, whereas others focus on community geriatrics in particular. Although originally a distinct clinical specialty, it has been integrated as a specialization of general medicine since the late 1970s.[31] Most geriatricians are, therefore, accredited for both. Unlike in the United States, geriatric medicine is a major specialty in the United Kingdom and are the single most numerous internal medicine specialists.

Canada

In Canada, there are two pathways that can be followed in order to work as a physician in a geriatric setting.

  1. Doctors of Medicine (M.D.) can complete a three-year core internal medicine residency program, followed by two years of specialized geriatrics residency training. This pathway leads to certification, and possibly fellowship after several years of supplementary academic training, by the Royal College of Physicians and Surgeons of Canada.
  2. Doctors of Medicine can opt for a two-year residency program in family medicine and complete a one-year enhanced skills program in care of the elderly. This post-doctoral pathway is accredited by the College of Family Physicians of Canada.

Many universities across Canada also offer gerontology training programs for the general public, such that nurses and other health care professionals can pursue further education in the discipline in order to better understand the process of aging and their role in the presence of older patients and residents.

India

In India, Geriatrics is a relatively new speciality offering. A three-year post graduate residency (M.D) training can be joined for after completing the 5.5-year undergraduate training of MBBS (Bachelor of Medicine and Bachelor of Surgery). Unfortunately, only eight major institutes provide M.D in Geriatric Medicine and subsequent training. Training in some institutes are exclusive in the Department of Geriatric Medicine, with rotations in Internal medicine, medical subspecialties etc. but in certain institutions, are limited to 2-year training in Internal medicine and subspecialities followed by one year of exclusive training in Geriatric Medicine.

Minimum geriatric competencies

In July 2007, the Association of American Medical Colleges (AAMC) and the John A. Hartford Foundation[32] hosted a National Consensus Conference on Competencies in Geriatric Education where a consensus was reached on minimum competencies (learning outcomes) that graduating medical students needed to assure competent care by new interns to older patients. Twenty-six (26) Minimum Geriatric Competencies in eight content domains were endorsed by the American Geriatrics Society (AGS), the American Medical Association (AMA), and the Association of Directors of Geriatric Academic Programs (ADGAP). The domains are: cognitive and behavioral disorders; medication management; self-care capacity; falls, balance, gait disorders; atypical presentation of disease; palliative care; hospital care for elders, and health care planning and promotion. Each content domain specifies three or more observable, measurable competencies.

Research

Hospital Elder Life Program

A prominent clinical challenge in geriatric medicine is the treatment and prevention of delirium. This is a condition in which hospitalized elderly patients become confused and disoriented when confronted with the uncertainty and confusion of a hospital stay. The health of the patient will decline as a result of delirium and can increase the length of hospitalization and lead to other health complications. The treatment of delirium involves keeping the patient mentally stimulated and oriented to reality, as well as providing specialized care in order to ensure that her/his needs are being met.

The Hospital Elder Life Program (HELP) is a model of hospital care developed at the Yale University School of Medicine. It is designed to prevent delirium and functional decline among elderly individuals in the hospital inpatient setting. HELP uses a core team of interdisciplinary staff and targeted intervention protocols to improve patients' outcomes and to provide cost-effective care. Unique to the program is the use of specially trained volunteers who carry out the majority of the non-clinical interventions.

In up to 40% of the cases, incident delirium can be prevented. To that end, HELP promotes interventions designed to maintain cognitive and physical functioning of older adults throughout the hospitalization, maximize patients' independence at discharge, assist with the transition from hospital to home and prevent unplanned hospital readmissions. Customized interventions include daily visitors; therapeutic activities to provide mental stimulation; daily exercise and walking assistance; sleep enhancement; nutritional support and hearing and vision protocols.

HELP has been replicated in over 63 hospitals across the world. Although the majority of the sites are based in the United States located in 25 different states, there is a growing international presence. International sites include: Australia, Canada, the Netherlands, Taiwan and the United Kingdom.

Pharmacology

Pharmacological constitution and regimen for older people is an important topic, one that is related to changing and differing physiology and psychology.

Changes in physiology with aging may alter the absorption, the effectiveness and the side effect profile of many drugs. These changes may occur in oral protective reflexes (dryness of the mouth caused by diminished salivary glands), in the gastrointestinal system (such as with delayed emptying of solids and liquids possibly restricting speed of absorption), and in the distribution of drugs with changes in body fat and muscle and drug elimination.

Psychological considerations include the fact that elderly persons (in particular, those experiencing substantial memory loss or other types of cognitive impairment) are unlikely to be able to adequately monitor and adhere to their own scheduled pharmacological administration. One study (Hutchinson et al., 2006) found that 25% of participants studied admitted to skipping doses or cutting them in half. Self-reported noncompliance with adherence to a medication schedule was reported by a striking one-third of the participants. Further development of methods that might possibly help monitor and regulate dosage administration and scheduling is an area that deserves attention.

Another important area is the potential for improper administration and use of potentially inappropriate medications, and the possibility of errors that could result in dangerous drug interactions. Polypharmacy is often a predictive factor (Cannon et al., 2006). Research done on home/community health care found that "nearly 1 of 3 medical regimens contain a potential medication error" (Choi et al., 2006).

Elderly persons sometimes cannot make decisions for themselves. They may have previously prepared a power of attorney and advance directives to provide guidance if they are unable to understand what is happening to them, whether this is due to long-term dementia or to a short-term, correctable problem, such as delirium from a fever.

Geriatricians must respect the patients' privacy while seeing that they receive appropriate and necessary services. More than most specialties, they must consider whether the patient has the legal responsibility and competence to understand the facts and make decisions. They must support informed consent and resist the temptation to manipulate the patient by withholding information, such as the dismal prognosis for a condition or the likelihood of recovering from surgery at home.

Elder abuse is the physical, financial, emotional, sexual, or other type of abuse of an older dependent. Adequate training, services, and support can reduce the likelihood of elder abuse, and proper attention can often identify it. For elderly people who are unable to care for themselves, geriatricians may recommend legal guardianship or conservatorship to care for the person or the estate.

Elder abuse occurs increasingly when caregivers of elderly relatives suffer from mental illness. These instances of abuse can be prevented by engaging these individuals with mental illness in mental health treatment. Additionally, interventions aimed at decreasing elder reliance on relatives may help decrease conflict and abuse. Family education and support programs conducted by mental health professionals may also be beneficial for elderly patients to learn how to set limits with relatives with psychiatric disorders without causing conflict that leads to abuse.[33]

See also

References

  1. ↑ "Definition of Geriatric medicine". MedicineNet. Archived from the original on 1 August 2020. Retrieved 10 April 2022.
  2. ↑ Geriatrics separation from internal medicine Archived 14 January 2009 at the Wayback Machine
  3. ↑ "Geriatric Medicine Specialty Description". American Medical Association. Archived from the original on 31 October 2020. Retrieved 5 September 2020.
  4. ↑ Fletcher C; Peto R (1977). "The natural history of chronic airflow obstruction". Br Med J. 1 (6077): 1645–8. doi:10.1136/bmj.1.6077.1645. PMC 1607732. PMID 871704.
  5. ↑ Qato, DM; Alexander GC; Conti RM; Johnson M; Schumm P; Lindau ST (24 December 2008). "Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States". JAMA. 300 (24): 2867–2878. doi:10.1001/jama.2008.892. PMC 2702513. PMID 19109115. Archived from the original on 7 November 2017. Retrieved 10 April 2022.
  6. ↑ Cruz-Jentoft, Alfonso J.; Baeyens, Jean Pierre; Bauer, Jürgen M.; Boirie, Yves; Cederholm, Tommy; Landi, Francesco; Martin, Finbarr C.; Michel, Jean-Pierre; Rolland, Yves; Schneider, Stéphane M.; Topinková, Eva (July 2010). "Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People". Age and Ageing. 39 (4): 412–423. doi:10.1093/ageing/afq034. ISSN 1468-2834. PMC 2886201. PMID 20392703.
  7. ↑ Cosh, Suzanne; Helmer, Catherine; Delcourt, Cecile; Robins, Tamara G; Tully, Phillip J (14 August 2019). "Depression in elderly patients with hearing loss: current perspectives". Clinical Interventions in Aging. 14: 1471–1480. doi:10.2147/CIA.S195824. ISSN 1176-9092. PMC 6698612. PMID 31616138.
  8. ↑ "Safe Use of Medicines for Older Adults". National Institute on Aging. Archived from the original on 6 April 2022. Retrieved 12 March 2021.
  9. 1 2 Makary MA, Segev DL, Pronovost PJ, et al. (June 2010). "Frailty as a predictor of surgical outcomes in older patients". J. Am. Coll. Surg. 210 (6): 901–8. doi:10.1016/j.jamcollsurg.2010.01.028. PMID 20510798. Lay summary (28 December 2010). {{cite journal}}: Cite uses deprecated parameter |lay-date= (help)
  10. ↑ "GERIATRICSFOR-SPECIALISTS INITIATIVE (GSI)" (PDF). Archived from the original (PDF) on 25 March 2009. Retrieved 9 February 2016.
  11. ↑ "Increasing Geriatrics Expertise in Surgical and Medical Specialties" (PDF). Archived from the original (PDF) on 25 March 2009. Retrieved 9 February 2016.
  12. ↑ Durgawati Devi; Rajeev Srivastava; B. K. Dwivedi (2010). "A critical review of concept of aging in Ayurveda". Ayu. 31 (4): 516–9. doi:10.4103/0974-8520.82030. PMC 3202253. PMID 22048551.
  13. ↑ Lascaratos, J.; Poulacou-Rebelacou, E. (2000). "The roots of geriatric medicine: Care of the aged in Byzantine times (324-1453 AD)". Gerontology. 46 (1): 2–6. doi:10.1159/000022125. PMID 11111221. S2CID 29651187.
  14. ↑ Howell, Trevor H. (January 1987). "Avicenna and His Regimen of Old Age". Age and Ageing. 16 (1): 58–9. doi:10.1093/ageing/16.1.58. PMID 3551552.
  15. ↑ Howell TH (1972). "Avicenna and the care of the aged". Gerontologist. 12 (4): 424–6. doi:10.1093/geront/12.4.424. PMID 4569393.
  16. ↑ Pitskhelauri GZ; Dzhorbenadze DA (1970). "Gerontology and geriatrics in the works of Abu Ali Ibn Sina (Avicenna) (on the 950th anniversary of the manuscript, Canon of Medical Science)". Sov Zdravookhr (in русский). 29 (10): 68–71. PMID 4931547.
  17. 1 2 Al Jazzar Archived 6 July 2008 at the Wayback Machine
  18. ↑ "Vesalius Official journal of the International Society for the History of Medicine" (PDF). Archived (PDF) from the original on 3 May 2012. Retrieved 10 April 2022.
  19. ↑ Algizar a web page in french Archived 7 April 2016 at the Wayback Machine
  20. ↑ "Islamic Medical Manuscripts: Bio-Bibliographies - I". www.nlm.nih.gov. Archived from the original on 23 July 2018. Retrieved 10 April 2022.
  21. ↑ Geritt Bos, Ibn al-Jazzar, Risala fi l-isyan (Treatise on forgetfulness), London, 1995
  22. ↑ "Islamic Culture and the Medical Arts: Specialized Literature". www.nlm.nih.gov. Archived from the original on 9 April 2019. Retrieved 10 April 2022.
  23. 1 2 Barton, A.; Mulley, G. (1 April 2003). "History of the development of geriatric medicine in the UK". Postgraduate Medical Journal. 79 (930): 229–234. doi:10.1136/pmj.79.930.229. ISSN 0032-5473. PMC 1742667. PMID 12743345.
  24. ↑ New bibliography of scientific papers by Dr. Laza K. Lazarević Archived 25 March 2012 at the Wayback Machine
  25. ↑ "Nascher/Manning Award". Archived from the original on 20 October 2012. Retrieved 1 November 2012.
  26. ↑ Achenbaum, W. Andrew; Albert, Daniel M. (1995). "Ignatz Leo Nascher". Profiles in Gerontology: A Biographical Dictionary. Greenwood. p. 256. ISBN 9780313292743.
  27. ↑ Denham MJ (2011). "Dr Marjory Warren CBE MRCS LRCP (1897-1960) the mother of British geriatric medicine". J Med Biogr. 19 (3): 105–10. doi:10.1258/jmb.2010.010030. PMID 21810847. S2CID 6847487.
  28. ↑ "A giant of geriatric medicine - Professor Bernard Isaacs (1924-1995)". British Geriatrics Society. Archived from the original on 24 October 2018. Retrieved 23 October 2018.
  29. ↑ Isaacs 1965
  30. ↑ "Department of Health Older People's information". Archived from the original on 5 March 2007. Retrieved 10 April 2022.
  31. ↑ Barton A; Mulley G (April 2003). "History of the development of geriatric medicine in the UK". Postgrad Med J. 79 (930): 229–34, quiz 233–4. doi:10.1136/pmj.79.930.229. PMC 1742667. PMID 12743345. Archived from the original on 20 August 2008. Retrieved 10 April 2022.
  32. ↑ "The John A. Hartford Foundation". www.jhartfound.org. Archived from the original on 1 March 2022. Retrieved 10 April 2022.
  33. ↑ Labrum T (2017). "Factors related to abuse of older persons by relatives with psychiatric disorders". Archives of Gerontology and Geriatrics. 68: 126–134. doi:10.1016/j.archger.2016.09.007. PMID 27810660.

Bibliography

  • Society of Certified Senior Advisors (2009). Working with Seniors Health, Financial and Social Issues".

Further reading

  • Cannon KT; Choi MM; Zuniga MA (June 2006). "Potentially inappropriate medication use in elderly patients receiving home health care: a retrospective data analysis". Am J Geriatr Pharmacother. 4 (2): 134–43. doi:10.1016/j.amjopharm.2006.06.010. PMID 16860260.
  • Gidal BE (January 2006). "Drug absorption in the elderly: biopharmaceutical considerations for the antiepileptic drugs". Epilepsy Res. 68 (Suppl 1): S65–9. doi:10.1016/j.eplepsyres.2005.07.018. PMID 16413756. S2CID 39671722.
  • Hutchison LC; Jones SK; West DS; Wei JY (June 2006). "Assessment of medication management by community-living elderly persons with two standardized assessment tools: a cross-sectional study". Am J Geriatr Pharmacother. 4 (2): 144–53. doi:10.1016/j.amjopharm.2006.06.009. PMID 16860261.
  • Isaacs B (1965). An introduction to geriatrics. London: Balliere, Tindall and Cassell.
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