Intracerebroventricular injection

Intracerebroventricular injection (also called ICV injection, i.c.v. injection, or sometimes ICVI) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood–brain barrier.[1] Although this barrier effectively protects the brain, it can prevent important medications from entering the CNS. The technique is widely used in biomedical research to introduce drugs, therapeutic RNAs, plasmid DNAs, and viral vectors into the CNS of diseased mice models.[2] It can also be used in human in cases of neurodegenerative disorders like spinal muscular atrophy (SMA), or administering chemotherapy in gliomas as well as delivering neurotrophic factors to CNS. It can be contrasted with intraperitoneal injection as an alternative choice of route of administration with differing pharmacokinetic and pharmacodynamic effects.[3]

The Ommaya reservoir is a catheter system invented by Ayub Ommaya, a Pakistani neurosurgeon in 1963. The reservoir is implanted under the scalp and attached to a catheter which is intracerebroventricularly inserted into the lateral ventricle.

References

  1. ↑ Lee, Mary; Desai, Archana (2007). Gibaldi's Drug Delivery Systems in Pharmaceutical Care. ASHP. p. 107. ISBN 9781585281367. Retrieved 26 March 2017.
  2. ↑ Glascock, Jacqueline J.; Osman, Erkan Y.; Coady, Tristan H.; Rose, Ferrill F.; Shababi, Monir; Lorson, Christian L. (3 October 2011). "Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice". J Vis Exp (56). doi:10.3791/2968. PMC 3227174. PMID 21988897.
  3. ↑ Cifuentes, M.; Pérez-Martín, M.; Grondona, J. M.; López-Ávalos, M. D.; Inagaki, N.; Granados-Durán, P.; Rivera, P.; Fernández-Llebrez, P. (2011-10-15). "A comparative analysis of intraperitoneal versus intracerebroventricular administration of bromodeoxyuridine for the study of cell proliferation in the adult rat brain". Journal of Neuroscience Methods. 201 (2): 307–314. doi:10.1016/j.jneumeth.2011.08.006. ISSN 1872-678X. PMID 21864575. S2CID 7087572.


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