GM1 gangliosidosis

The long-term outlook (prognosis) for people with GM1 gangliosidosis (GM1) depends on the type, age of onset, and severity of the condition in each person.

Type 1, also known as the infantile form, is the most severe type of GM1. Children with type 1 usually do not survive past early childhood due to infection and cardiopulmonary failure. Type 2, which includes the late-infantile and juvenile forms, is an intermediate form of the condition. People with type 2 who have late-infantile onset usually survive into mid-childhood, while those with juvenile onset may live into early adulthood. Type 3, known as the adult or chronic form of GM1, is the mildest form of the condition. The age of onset and life expectancy for people with type 3 varies, but life expectancy is usually shortened.^[1][2]