National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Multifocal motor neuropathy

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Is multifocal motor neuropathy hereditary? We have no family history that I know of. My son was diagnosed with MMN at age 29, if he has children are they at risk?

The following information may help to address your question:


Is multifocal motor neuropathy inherited?

We are not aware of any evidence that multifocal motor neuropathy (MMN) is inherited or of any reports of familial cases (occurring in more than one person in a family). Furthermore, to our knowledge, no specific genes known to be associated with MMN have been identified.
Last updated: 3/7/2016

What causes multifocal motor neuropathy?

The exact underlying cause of multifocal motor neuropathy (MMN) is poorly understood. It is considered an immune-mediated disorder (due to an abnormal immune system response), both because IVIG therapy improves symptoms, and many patients have anti-GM1 antibodies. Research to further understand the cause of MMN is underway.[1][2]
Last updated: 3/7/2016

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

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GARD Information Specialist

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  1. Lange D and Robinson-Papp J. Multifocal motor neuropathy. UpToDate. Waltham, MA: UpToDate; 2016; http://www.uptodate.com/contents/multifocal-motor-neuropathy.
  2. MMN Overview. GBS/CIDP Foundation International. 2016; http://www.gbs-cidp.org/variants/mmn-overview/.