National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2)


Other Names:
AML with inv3(p21;q26.2) or t(3;3)(p21;q26.2); Acute myeloid leukemia with inv3(q21;q26.2) or t(3;3)(q21;q26.2); AML with inv3(q21;q26.2) or t(3;3)(q21;q26.2); AML with inv3(p21;q26.2) or t(3;3)(p21;q26.2); Acute myeloid leukemia with inv3(q21;q26.2) or t(3;3)(q21;q26.2); AML with inv3(q21;q26.2) or t(3;3)(q21;q26.2); Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); AML with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) See More
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The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.
orphanet

Orpha Number: 402020

Definition
A subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and, rarely, other tissues. Bone marrow typically shows small, hypolobated megakaryocytes and multilineage dyslplasia. Patients typically present with leukocytosis, anemia, variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported.

Visit the Orphanet disease page for more resources.
Last updated: 4/1/2018

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.

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