National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

McPherson Clemens syndrome



Other Names:
Cleft lip, cleft palate, characteristic facies, intestinal malrotation, and lethal congenital heart disease
Categories:

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

Showing of 17 |
Medical Terms Other Names
Learn More:
HPO ID
Percent of people who have these symptoms is not available through HPO
Abnormal hand morphology
Abnormal shape of hand
0005922
Abnormality of cardiovascular system morphology 0030680
Abnormality of the tongue
Abnormal tongue
Tongue abnormality
[ more ]
0000157
Autosomal recessive inheritance 0000007
Bilateral cleft lip and palate
Right and left cleft lip and palate
0002744
Broad palm
Broad hand
Broad hands
Wide palm
[ more ]
0001169
Cleft upper lip
Harelip
0000204
Flat face
Flat facial shape
0012368
Flat occiput 0005469
Hypertelorism
Wide-set eyes
Widely spaced eyes
[ more ]
0000316
Intestinal malrotation 0002566
Large for gestational age
Birth weight > 90th percentile
Birthweight > 90th percentile
[ more ]
0001520
Malar flattening
Zygomatic flattening
0000272
Pancreatic islet-cell hyperplasia 0004510
Partial duplication of thumb phalanx
Partial duplication of the thumb bones
0009944
Short palm 0004279
Visceromegaly 0003271
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Last updated: 7/1/2020

If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.

If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.

You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.

Healthcare Resources


These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss McPherson Clemens syndrome. Click on the link to view a sample search on this topic.

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