National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Anodontia

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I was born with no permanent teeth at all. No one else in my family has this condition. What are the chances that my offspring may also have this condition?

The following information may help to address your question:


What is anodontia?

Anodontia is a dental condition characterized by complete absence of teeth.[1][2] The primary (baby) or permanent (adult) teeth may be involved.[1] Anodontia is extremely rare when present in a pure form (without associated abnormalities). In most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias.[1][2] In these cases, abnormalities are also noted in the hair, nails, and sweat glands. Anodontia is an autosomal recessive condition. A specific gene has not yet been identified.[1] Treatment involves replacement of the teeth with dentures or implants.[1][2]
Last updated: 10/7/2015

How is anodontia inherited?

Anodontia is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations.[1][3] The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Last updated: 10/7/2015

Are my children at-risk for this condition?

The offspring of an individual with anodontia are obligate carriers  (heterozygotes) of the condition.As mentioned above, carriers typically do not show signs and symptoms of the condition. We encourage you to discuss your questions and concerns related to the risks to your children with a genetics professional. 
Last updated: 10/7/2015

How can I find a genetics professional in my area?

To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by GeneTests, the American College of Medical Genetics, and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference.
Last updated: 8/23/2016

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

Warm regards,
GARD Information Specialist

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  1. Anodontia. National Organization for Rare Disorders (NORD). 2006; http://rarediseases.org/rare-diseases/anodontia/. Accessed 10/7/2015.
  2. Bloch-Zupan A. Anodontia. Orphanet. January 2013; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=99797. Accessed 10/7/2015.
  3. ANODONTIA OF PERMANENT DENTITION. Online Mendelian Inheritance in Man (OMIM). August 19, 2009; http://www.omim.org/clinicalSynopsis/206780. Accessed 10/7/2015.