National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Intrahepatic cholangiocarcinoma

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Is there a cure for this horrible disease? Also are there any new research trials going on now for people recently diagnosed with this disease?

The following information may help to address your question:


What is intrahepatic cholangiocarcinoma?

Intrahepatic cholangiocarcinoma is a cancer that develops in the cells within the bile ducts; both inside and outside the liver. The terms cholangiocarinoma and bile duct cancer are often used to refer to the same condition. This condition occurs slightly more often in males than females and usually affects people who are between 50-70 years old. Signs and symptoms of intrahepatic cholangiocarcinoma include jaundice, abdominal pain, fever, weight loss, weakness and itching. Treatment options may include surgery to remove the bile duct and parts of the liver, chemotherapy and radiation.[1]
Last updated: 4/1/2014

How might intrahepatic cholangiocarcinoma be treated? Can it be cured?

Surgery to completely remove the bile duct and tumor is the only option that can possibly lead to a cure for patients. The type of operation will depend on the size and location of the cancer. For cases of intrahepatic cancers that cannot be surgically removed, a liver transplantation may be an option. In some cases, a liver transplant might even cure the cancer. Finally, radiation and chemotherapy are also treatment options available for intrahepatic cholangiocarcioma either in addition to surgery or on their own.[2]
Last updated: 4/1/2014

How can I find out about clinical research studies involving intrahepatic cholangiocarcinoma?

ClinicalTrials.gov lists trials that are studying or have studied Intrahepatic cholangiocarcinoma. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.After you click on a study, review its "eligibility" criteria to determine its appropriateness. Use the study’s contact information to learn more. Check this site often for regular updates.
Last updated: 4/1/2014

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

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GARD Information Specialist

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  1. Bile Duct Cancer (Cholangiocarcinoma). Johns Hopkins Medicine Liver Tumor Center. http://www.hopkinsmedicine.org/liver_tumor_center/conditions/bile_duct_cancer.html. Accessed 4/1/2014.
  2. Bile Duct Cancer (Cholangiocarcinoma). American Cancer Society. October 30, 2013; http://www.cancer.org/acs/groups/cid/documents/webcontent/003084-pdf.pdf. Accessed 4/1/2014.