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Dubin-Johnson syndrome

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I have Dubin-Johnson syndrome. Can this condition be passed along to another individual through sexual intercourse?

The following information may help to address your question:


What is Dubin-Johnson syndrome?

Dubin-Johnson syndrome (DJS) is an inherited disorder of bilirubin characterized by a buildup of bilirubin in the bloodstream (hyperbilirubinemia). When bilirubin builds up in the skin and the whites of the eyes, it can cause a yellowish color to the skin (jaundice). Individuals with DJS may also have a liver that is sometimes enlarged and tender.[1] The symptoms often do not present until puberty or adulthood. Factors that may worsen symptoms include: alcohol use, birth control pills, infection, and pregnancy. In most cases, treatment is not required.[2][3] 
Last updated: 6/17/2016

What causes Dubin-Johnson syndrome (DJS)?

DJS is a genetic disorder caused by mutations in the ABCC2 gene. The ABCC2 gene codes for a protein called multidrug resistance protein 2 (MRP2). MRP2 transports substances out of cells. It is primarily found in the liver, but can also be found in the kidneys, intestine, and placenta during pregnancy.[4]

Mutations in the ABCC2 gene affect the structure and function of the MRP2 protein. This may disrupt the body's ability to rid itself of bilirubin, resulting in a build up.[4] 
Last updated: 6/17/2016

How is Dubin-Johnson syndrome (DJS) inherited?

DJS is inherited in an autosomal recessive manner.[5] This means that to be affected, a person must have a mutation in both copies of the responsible gene in each cell. Affected people inherit one mutated copy of the gene from each parent, who is referred to as a carrier. Carriers of an autosomal recessive condition typically do not have any signs or symptoms (they are unaffected). When 2 carriers of an autosomal recessive condition have children, each child has a:
  • 25% (1 in 4) chance to be affected
  • 50% (1 in 2) chance to be an unaffected carrier like each parent
  • 25% (1 in 4) chance to be unaffected and not be a carrier
Last updated: 6/17/2016

Can Dubin-Johnsons syndrome (DJS) be passed along to another individual through sexual intercourse?

No, DJS is caused by a gene mutation that is passed down (inherited) through families.[1] It is not a contagious condition and cannot be passed along to another individual through sexual intercourse.
Last updated: 6/17/2016

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

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  1. Dubin Johnson Syndrome. National Organization for Rare Disorders (NORD). 2007; http://rarediseases.org/rare-diseases/dubin-johnson-syndrome/. Accessed 6/17/2016.
  2. Simon S Rabinowitz. Dubin-Johnson Syndrome. Medscape. Jun 24, 2015; http://emedicine.medscape.com/article/173517-overview.
  3. Dugdale, DC. Dubin-Johnson syndrome. MedlinePlus. 8/17/2014; http://www.nlm.nih.gov/medlineplus/ency/article/000242.htm.
  4. ABCC2. Genetics Home Reference. March 2009; https://ghr.nlm.nih.gov/gene/ABCC2. Accessed 6/17/2016.
  5. Dubin-Johnson syndrome. Genetics Home Reference. March 2009; https://ghr.nlm.nih.gov/condition/dubin-johnson-syndrome. Accessed 6/17/2016.