This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
| Medical Terms | Other Names | Learn More: HPO ID |
|---|---|---|
| 80%-99% of people have these symptoms | ||
| Arthralgia |
Joint pain
|
0002829 |
| Bone pain | 0002653 | |
| Chest pain | 0100749 | |
| Craniofacial osteosclerosis | 0005464 | |
| Enthesitis | 0100686 | |
| Hyperostosis |
Bone overgrowth
|
0100774 |
|
Skeletal tumor
|
0010622 | |
| Osteolysis |
Breakdown of bone
|
0002797 |
| Synovitis | 0100769 | |
| 30%-79% of people have these symptoms | ||
| Abnormality of the sacroiliac joint | 0100781 | |
| Acne | 0001061 | |
|
Joint inflammation
|
0001369 | |
| Edema |
Fluid retention
Water retention
[ more ]
|
0000969 |
| Osteomyelitis |
Bone infection
|
0002754 |
| Palmoplantar pustulosis | 0100847 | |
| Psoriasiform dermatitis | 0003765 | |
| 5%-29% of people have these symptoms | ||
| Abdominal pain |
Pain in stomach
Stomach pain
[ more ]
|
0002027 |
| Chronic diarrhea | 0002028 | |
| Cranial nerve paralysis | 0006824 | |
| Inflammation of the large intestine | 0002037 | |
| Recurrent fractures |
Increased fracture rate
Increased fractures
Multiple fractures
Multiple spontaneous fractures
Varying degree of multiple fractures
[ more ]
|
0002757 |
| Recurrent skin infections |
Skin infections, recurrent
|
0001581 |
| Skin rash | 0000988 | |
| Steatorrhea |
Fat in feces
|
0002570 |
| Vasculitis |
Inflammation of blood vessel
|
0002633 |
| Venous thrombosis |
Blood clot in vein
|
0004936 |
Other drugs that may be used include:
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
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Conditions with similar signs and symptoms from Orphanet
|
|---|
|
Differential diagnosis includes infectious osteomyelitis or arthritis, Langerhans cell histiocytosis, and bone tumors such as Ewing sarcoma, osteoblastoma, and osteoid osteoma. Hypophosphatasia may mimic the bone phenotype of SAPHO syndrome.
Visit the
Orphanet disease page
for more information.
|
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
Are there any specialists in the San Diego, CA, area for Sapho Syndrome? Where can I find information on recommended treatments? Any information would be helpful. See answer
