National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Sutton disease 2

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My son suffers from recurrent aphthous stomatitis or Sutton disease 2. It took us 20 months to be given this diagnosis. I searched for diagnosis on the web site but did not find any information. Is there any information about Sutton disease 2 that I am somehow missing I am trying to become educated about his disease.

The following information may help to address your question:


What is Sutton disease 2?

Sutton disease 2, also known as recurrent aphthous stomatitis, is a chronic inflammatory disease characterized by painful ulcers in the mouth.[1][2] These sores, which can be of varying size and frequency, are commonly called canker sores. The exact cause of this condition is not fully understood, although it may be due to an abnormal immune response.[2] Treatment is not always necessary, but may include mouth rinses, topical ointments or systemic corticosteroids.[3]
Last updated: 2/17/2013

How is Sutton disease 2 diagnosed?

The diagnosis of canker sores (including Sutton disease 2) is usually based on clinical examination and medical history. There are no laboratory procedures available for definitive diagnosis.[1][3] In some cases, tests may be used to check for other health problems, especially if the canker sores are severe or ongoing (lasting more than 10 to 14 days).[3][4] Dentists and/or professionals trained in oral medicine can assist in the diagnosis.[4] 

Further information about the diagnosis of Sutton disease 2 can be accessed through Medscape Reference.

Last updated: 2/17/2013

How might Sutton disease 2 be treated?

Treatment may not be necessary for minor canker sores which tend to clear on their own over the course of a week or two. Large, persistent or unusually painful sores may require medical care.[3] The goals of treatment are to decrease pain, speed healing and avoid recurrence. While no one therapy meets all of these goals, many do offer some benefit.[4] Treatment may include mouth rinses, topical ointments or systemic corticosteroids.[3]

More detailed information about treatment options can be accessed through the Treatment and Medication sections of Medscape Reference and through the American Academy of Oral Medicine.

Last updated: 2/17/2013

We hope this information is helpful. We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us.

Warm regards,
GARD Information Specialist

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  1. Plewa MC. Pediatric Aphthous Ulcers. Medscape Reference. March 28, 2012; http://emedicine.medscape.com/article/909213-overview. Accessed 2/17/2013.
  2. Sutton Disease II. National Organization for Rare Disorders (NORD). 2003; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/203/viewAbstract. Accessed 2/17/2013.
  3. Canker sore. MayoClinic.com. March 24, 2012; http://www.mayoclinic.com/health/canker-sore/DS00354/METHOD=print. Accessed 2/17/2013.
  4. Canker Sores - Treatment. The American Academy of Oral Medicine. December 2007; http://www.aaom.com/index.php?option=com_content&view=article&id=82:canker-sores&catid=22:patient-condition-information&Itemid=120. Accessed 2/17/2013.