National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Pallidopyramidal syndrome



Other Names:
Pallido-pyramidal disease
Categories:

The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.
orphanet

Orpha Number: 171695

Definition
Parkinsonian-pyramidal syndrome is a rare, genetic, neurological disorder characterized by the association of both parkinsonian (i.e. bradykinesia, rigidity and/or rest tremor) and pyramidal (i.e. increased reflexes, extensor plantar reflexes, pyramidal weakness or spasticity) manifestations, which vary according to the underlying associated disease (e.g. neurodegenerative disease, inborn errors of metabolism).

Visit the Orphanet disease page for more resources.
Last updated: 11/1/2018

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

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Medical Terms Other Names
Learn More:
HPO ID
100% of people have these symptoms
Parkinsonism 0001300
30%-79% of people have these symptoms
Abnormal autonomic nervous system physiology 0012332
Babinski sign 0003487
Bradykinesia
Slow movements
Slowness of movements
[ more ]
0002067
Dysphagia
Poor swallowing
Swallowing difficulties
Swallowing difficulty
[ more ]
0002015
Dystonia 0001332
Hyperreflexia
Increased reflexes
0001347
Hypomimic face
Dull facial expression
0000338
Intention tremor 0002080
Monotonic speech 0031435
Myoclonus 0001336
Neurogenic bladder
Lack of bladder control due to nervous system injury
0000011
Postural instability
Balance impairment
0002172
Rigidity
Muscle rigidity
0002063
Shuffling gait
Shuffled walk
0002362
Sleep disturbance
Difficulty sleeping
Trouble sleeping
[ more ]
0002360
Slow saccadic eye movements
Slow eye movements
0000514
Spasticity
Involuntary muscle stiffness, contraction, or spasm
0001257
Substantia nigra gliosis 0011960
Talipes equinovarus
Club feet
Club foot
Clubfeet
Clubfoot
[ more ]
0001762
Visual hallucinations 0002367
5%-29% of people have these symptoms
Dementia
Dementia, progressive
Progressive dementia
[ more ]
0000726
Lewy bodies 0100315
Percent of people who have these symptoms is not available through HPO
Abnormality of extrapyramidal motor function 0002071
Autosomal recessive inheritance 0000007
Dysarthria
Difficulty articulating speech
0001260
Lower limb spasticity 0002061
Parkinsonism with favorable response to dopaminergic medication 0002548
Scissor gait
Scissor walk
Scissors gait
[ more ]
0012407
Slow progression
Signs and symptoms worsen slowly with time
0003677
Tremor 0001337
Young adult onset 0011462
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Last updated: 7/1/2020

If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.

If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.

You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.

Healthcare Resources


These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pallidopyramidal syndrome. Click on the link to view a sample search on this topic.

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