National Center for Advancing and Translational Sciences Genetic and Rare Diseases Information Center, a program of the National Center for Advancing and Translational Sciences

Adenosarcoma of the uterus

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Is radiation and/or chemotherapy considered appropriate if uterine adenosarcoma shows signs of spreading to the lymph node? Is ifosfamid an appropriate treatment? Is it available as an oral medication?
The recommended treatment option for adenosarcoma of the uterus is surgery. Total hysterectomy with bilateral salpingo-oophorectomy can cure this condition if it is only in the uterus. Adjuvant radiation therapy can help lower the chance of the tumor coming back. There is limited data and no agreement regarding the benefit of adjuvant chemotherapy. Chemotherapy or whole abdomen radiation therapy is used for disease that has spread into the intraperitoneal region. The chemotherapy agents consist of either doxorubicin or a combination of cisplatin and ifosfamide with mesna.[1] Ifosfamide is not available in an oral form; it is given by injection into a vein.
Last updated: 3/22/2013

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  1. Mirna Farha, Elie Hobeika, Ghada Moumneh and Anwar Nassar. Uterine mullerian adenosarcoma with sarcomatous overgrowth fatal recurrence within two weeks of diagnosis: a case report. Journal of Medical Case Reports. 2007; 1:103. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2098769/. Accessed 3/22/2013.