MX1

MX dynamin like GTPase 1
المعرفات
الأسماء المستعارة	interferon-induced protein p78, myxoma resistance protein 1, Myxovirus resistance protein 1, interferon-regulated resistance GTP-binding protein MxA, IFI-78K, interferon-inducible protein p78, myxovirus (influenza virus) resistance 1, interferon-inducible protein p78, MX1, interferon-induced GTP-binding protein Mx1
معرفات خارجية
أورثولوج
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

MX1‏ (MX dynamin like GTPase 1) هوَ بروتين يُشَفر بواسطة جين MX1 في الإنسان.[1][2]

المراجع

"Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)"، مؤرشف من الأصل في 05 ديسمبر 2010.
Haller O, Staeheli P, Kochs G (يوليو 2007)، "Interferon-induced Mx proteins in antiviral host defense"، Biochimie، 89 (6–7): 812–8، doi:10.1016/j.biochi.2007.04.015، PMID 17570575.

قراءة متعمقة

Pavlovic J, Haller O, Staeheli P (1992)، "Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle"، J. Virol.، 66 (4): 2564–9، PMC 289059، PMID 1548781.
Horisberger MA (1992)، "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins"، J. Virol.، 66 (8): 4705–9، PMC 241296، PMID 1629950.
Petersen MB, Slaugenhaupt SA, Lewis JG, وآخرون (1991)، "A genetic linkage map of 27 markers on human chromosome 21"، Genomics، 9 (3): 407–19، doi:10.1016/0888-7543(91)90406-5، PMID 1674496.
Horisberger MA, McMaster GK, Zeller H, وآخرون (1990)، "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter"، J. Virol.، 64 (3): 1171–81، PMC 249231، PMID 2154602.
Pavlovic J, Zürcher T, Haller O, Staeheli P (1990)، "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein"، J. Virol.، 64 (7): 3370–5، PMC 249583، PMID 2161946.
Aebi M, Fäh J, Hurt N, وآخرون (1990)، "cDNA structures and regulation of two interferon-induced human Mx proteins"، Mol. Cell. Biol.، 9 (11): 5062–72، PMC 363658، PMID 2481229.
Weitz G, Bekisz J, Zoon K, Arnheiter H (1990)، "Purification and characterization of a human Mx protein"، J. Interferon Res.، 9 (6): 679–89، doi:10.1089/jir.1989.9.679، PMID 2607176.
Maruyama K, Sugano S (1994)، "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides"، Gene، 138 (1–2): 171–4، doi:10.1016/0378-1119(94)90802-8، PMID 8125298.
Melén K, Keskinen P, Ronni T, وآخرون (1996)، "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope"، J. Biol. Chem.، 271 (38): 23478–86، doi:10.1074/jbc.271.38.23478، PMID 8798556.
Ponten A, Sick C, Weeber M, وآخرون (1997)، "Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity"، J. Virol.، 71 (4): 2591–9، PMC 191379، PMID 9060610.
Fernández M, Quiroga JA, Martín J, وآخرون (1997)، "Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection"، J. Med. Virol.، 51 (4): 332–7، doi:10.1002/(SICI)1096-9071(199704)51:4<332::AID-JMV12>3.0.CO;2-K، PMID 9093949.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, وآخرون (1997)، "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library"، Gene، 200 (1–2): 149–56، doi:10.1016/S0378-1119(97)00411-3، PMID 9373149.
Li Y, Youssoufian H (1998)، "MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups"، J. Clin. Invest.، 100 (11): 2873–80، doi:10.1172/JCI119836، PMC 508494، PMID 9389754.
Kochs G, Trost M, Janzen C, Haller O (1998)، "MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures"، Methods، 15 (3): 255–63، doi:10.1006/meth.1998.0629، PMID 9735310.
Weber F, Haller O, Kochs G (2000)، "MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes"، J. Virol.، 74 (1): 560–3، doi:10.1128/JVI.74.1.560-563.2000، PMC 111572، PMID 10590150.
Hattori M, Fujiyama A, Taylor TD, وآخرون (2000)، "The DNA sequence of human chromosome 21"، Nature، 405 (6784): 311–9، doi:10.1038/35012518، PMID 10830953.
Hijikata M, Ohta Y, Mishiro S (2000)، "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon"، Intervirology، 43 (2): 124–7، doi:10.1159/000025035، PMID 10971132.
Engelhardt OG, Ullrich E, Kochs G, Haller O (2002)، "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies"، Exp. Cell Res.، 271 (2): 286–95، doi:10.1006/excr.2001.5380، PMID 11716541.
Hijikata M, Mishiro S, Miyamoto C, وآخرون (2002)، "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro"، Intervirology، 44 (6): 379–82، doi:10.1159/000050075، PMID 11805446.
Kochs G, Haener M, Aebi U, Haller O (2002)، "Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers"، J. Biol. Chem.، 277 (16): 14172–6، doi:10.1074/jbc.M200244200، PMID 11847228.

بوابة الكيمياء الحيوية
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

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[entrez-1] "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)"، مؤرشف من الأصل في 05 ديسمبر 2010.

[pmid17570575-2] Haller O, Staeheli P, Kochs G (يوليو 2007)، "Interferon-induced Mx proteins in antiviral host defense"، Biochimie، 89 (6–7): 812–8، doi:10.1016/j.biochi.2007.04.015، PMID 17570575.