(+)-Caryolan-1-ol synthase

(+)-Caryolan-1-ol synthase (EC 4.2.1.138, GcoA) is an enzyme with systematic name (+)-β-caryophyllene hydrolase (cyclizing, (+)-caryolan-1-ol-forming).[1] This enzyme catalyses the following chemical reaction

(+)-β-caryophyllene + H2O (+)-caryolan-1-ol
(+)-Caryolan-1-ol synthase
Identifiers
EC no.4.2.1.138
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme also forms (+)-β-caryophyllene from farnesyl diphosphate (EC 4.2.3.89).

References

  1. Nakano C, Horinouchi S, Ohnishi Y (August 2011). "Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus". The Journal of Biological Chemistry. 286 (32): 27980–7. doi:10.1074/jbc.m111.265652. PMC 3151043. PMID 21693706.
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