(-)-alpha-cuprenene synthase
(–)-α-Cuprenene synthase (EC 4.2.3.95, Cop6) is an enzyme with systematic name (–)-α -cuprenene hydrolase (cyclizing, (–)-α-cuprenene-forming).[1] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate (–)-α-cuprenene + diphosphate
| (–)-α-cuprenene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.95 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from the fungus Coprinopsis cinerea produces (–)-α-cuprenene with high selectivity.
References
- Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C (May 2010). "Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers". ChemBioChem. 11 (8): 1093–106. doi:10.1002/cbic.200900671. PMC 2873112. PMID 20419721.
External links
- (-)-alpha-cuprenene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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