(S)-coclaurine-N-methyltransferase

In enzymology, a (S)-coclaurine-N-methyltransferase (EC 2.1.1.140) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + (S)-coclaurine S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
(S)-coclaurine-N-methyltransferase
Identifiers
EC no.2.1.1.140
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and (S)-coclaurine, whereas its two products are S-adenosylhomocysteine and (S)-N-methylcoclaurine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase. This enzyme participates in alkaloid biosynthesis i.

References

    • Loeffler S, Deus-Neumann B, Zenk MH (1995). "S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia". Phytochemistry. 38 (6): 1387–1395. doi:10.1016/0031-9422(94)00813-9.


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