Phenylpiperazine

1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.[1]

Phenylpiperazine
Skeletal formula of phenylpiperazine
Ball-and-stick model of the phenylpiperazine molecule
Names
Preferred IUPAC name
1-Phenylpiperazine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.001.969
UNII
  • InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2 checkY
    Key: YZTJYBJCZXZGCT-UHFFFAOYSA-N checkY
  • c1cc(ccc1)N2CCNCC2
Properties
C10H14N2
Molar mass 162.23 g/mol
Appearance clear colourless to yellow liquid
Density 1.028g/cm3
Melting point 18.8 °C (65.8 °F; 291.9 K)
Boiling point 287.2 °C (549.0 °F; 560.3 K) at 760mmHg
insoluble
Hazards
Flash point 138.3 °C (280.9 °F; 411.4 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

1-Phenylpiperazine is toxic, its oral LD50 in rats is 210 mg/kg.[2]

List phenylpiperazine derivatives
  1. Alpertine [27076-46-6]
  2. BP 554 [82900-57-0]
  3. Butropipazone [2354-61-2]
  4. CAM89 alluded to here: WO 2018102233
  5. Centphenaquin [98459-16-6]
  6. Centpropazine [91315-34-3] [34675-77-9]
  7. Clodoxopone [71923-34-7]
  8. Dropropizine [17692-31-8]
  9. Etoperidone
  10. FAUC-299 [313972-96-2]
  11. FAUC-312 [562104-72-7]
  12. LASSBio-579 [591774-47-9]
  13. LASSBio-581 [591774-48-0]
  14. LASSBio-632
  15. LASSBio-680
  16. LASSBio-724
  17. LASSBio-729 [66307-58-2]
  18. LASSBio-730
  19. McN 261 [1044-59-3]
  20. Nefazodone
  21. Niaprazine
  22. Oxypertine
  23. PD-158771 [189152-50-9]
  24. PO-219
  25. Trazodone
  26. WIN 18,437 [4121-77-1]

See also

References
  1. World Health Organization (WHO) (2006). "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). Archived from the original (PDF) on 2008-12-14. Retrieved 27 April 2010.
  2. "1-Phenylpiperazine".


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