16S rRNA (guanine1207-N2)-methyltransferase

16S rRNA (guanine1207-N2)-methyltransferase (EC 2.1.1.172, m2G1207 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine1207 in 16S rRNA S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
16S rRNA (guanine1207-N2)-methyltransferase
Identifiers
EC no.2.1.1.172
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA.

References

  1. Tscherne JS, Nurse K, Popienick P, Ofengand J (January 1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli". The Journal of Biological Chemistry. 274 (2): 924–9. doi:10.1074/jbc.274.2.924. PMID 9873033.
  2. Sunita S, Purta E, Durawa M, Tkaczuk KL, Swaathi J, Bujnicki JM, Sivaraman J (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC". Nucleic Acids Research. 35 (13): 4264–74. doi:10.1093/nar/gkm411. PMC 1934991. PMID 17576679.
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