16S rRNA (guanine966-N2)-methyltransferase

16S rRNA (guanine966-N2)-methyltransferase (EC 2.1.1.171, yhhF (gene), rsmD (gene), m2G966 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine966-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine966 in 16S rRNA S-adenosyl-L-homocysteine + N2-methylguanine966 in 16S rRNA
16S rRNA (guanine966-N2)-methyltransferase
Identifiers
EC no.2.1.1.171
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme efficiently methylates guanine966 of the assembled 30S subunits in vitro.

References

  1. Lesnyak DV, Osipiuk J, Skarina T, Sergiev PV, Bogdanov AA, Edwards A, Savchenko A, Joachimiak A, Dontsova OA (February 2007). "Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure". The Journal of Biological Chemistry. 282 (8): 5880–7. doi:10.1074/jbc.m608214200. PMC 2885967. PMID 17189261.
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