2,2'-Dipyridyldisulfide

2,2′-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols[1][2] and activating carboxylic acid for coupling reactions, as in the following reaction:[3]

2,2′-Dipyridyldisulfide
Skeletal formula of DPS
Space-filling model of the DPS molecule
Names
Preferred IUPAC name
2,2′-Disulfanediyldipyridine
Other names
1,2-Di(pyridin-2-yl)disulfane (not recommended)
2,2′-Dipyridyldisulfide
2,2′-Dipyridyldisulphide
Aldrithiol-2
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.016.676
EC Number
  • 218-343-1
UNII
  • InChI=1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H checkY
    Key: HAXFWIACAGNFHA-UHFFFAOYSA-N checkY
  • InChI=1/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H
    Key: HAXFWIACAGNFHA-UHFFFAOYAJ
  • S(Sc1ncccc1)c2ncccc2
  • c1ccnc(c1)SSc2ccccn2
Properties
C10H8N2S2
Molar mass 220.31 g·mol−1
Melting point 56 to 58 °C (133 to 136 °F; 329 to 331 K)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Irritant (Xi)
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Uses

It is also used in molecular biology as an oxidising agent, for example to oxidise free thiols to form disulfide bonds in proteins.

References

  1. Futaki S. and Kitagawa K. (1994). "Peptide-Unit Assembling Using Disulfide Cross-Linking - a New Approach for Construction of Protein Models". Tetrahedron Lett. 35 (8): 1267–1270. doi:10.1016/0040-4039(94)88040-9.
  2. "Special Reagents for Thiol Groups". Aldrichimica Acta. 4 (3): 33–46.
  3. Thalmann A., Oertle K. and Gerlach H (1985). "Ricinelaidic acid lactone". Org. Synth. 7: 470. doi:10.15227/orgsyn.063.0192.


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