2,5-diaminovalerate transaminase

In enzymology, a 2,5-diaminovalerate transaminase (EC 2.6.1.8) is an enzyme that catalyzes the chemical reaction

2,5-diaminopentanoate + 2-oxoglutarate 5-amino-2-oxopentanoate + L-glutamate
2,5-diaminovalerate transaminase
Identifiers
EC no.2.6.1.8
CAS no.9030-39-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are 2,5-diaminopentanoate and 2-oxoglutarate, whereas its two products are 5-amino-2-oxopentanoate and L-glutamate.

It employs one cofactor, pyridoxal phosphate.

Nomenclature

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 2,5-diaminopentanoate:2-oxoglutarate aminotransferase. Other names in common use include diamino-acid transaminase, and diamino acid aminotransferase.

References

    • Roberts E (February 1954). "Studies of transamination". Archives of Biochemistry and Biophysics. 48 (2): 395–401. doi:10.1016/0003-9861(54)90355-0. PMID 13125615.


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