2010 Major League Baseball postseason

1. Tampa Bay Rays – AL East champions, 96–66[2]
2. Minnesota Twins – AL Central champions, 94–68[3]
3. Texas Rangers – AL West champions, 90–72[4]
4. New York Yankees – AL Wild Card qualifier, 95–67[5]

1. Philadelphia Phillies – NL East champions, 97–65[6]
2. San Francisco Giants – NL West champions, 92–70[7]
3. Cincinnati Reds – NL Central champions, 91–71[8]
4. Atlanta Braves – NL Wild Card qualifier, 91–71[9]

Texas won the series, 3–2.

This was the first postseason meeting between the Rays and Rangers. In the first postseason series where neither team won a home game, the Rangers defeated the Rays in five games to advance to the ALCS for the first time in franchise history.

The Rangers dominated the first two games in Tampa, thanks to solid pitching performances from Cliff Lee and C. J. Wilson. When the series shifted to Arlington for Game 3, the Rangers possessed a 2–1 lead going into the eighth, but the Rays went on a 5–1 run through the eighth and ninth innings to win and avoid a sweep. In Game 4, the Rays jumped out to an early lead and did not relinquish it, sending the series back to Tampa for Game 5. However, Lee would yet again lead the Rangers to victory, pitching a complete game and giving the Rangers their first playoff series victory.

The Rays and Rangers met again in the ALDS the next year, which the Rangers also won, but this time in four games.

New York won the series, 3–0.

This was the fourth postseason meeting between the Yankees and Twins (2003, 2004, 2009). The Yankees once again swept the Twins to advance to the ALCS for the second year in a row.

In Minneapolis, the Yankees stole Game 1 by a 6–4 score. In Game 2, Andy Pettitte helped lead the Yankees to victory in what would be his nineteenth and final postseason win. When the series moved to the Bronx, Phil Hughes and the Yankees bullpen held the Twins to one run scored to complete the sweep.

The Twins would not return to the postseason again until 2017.

Philadelphia won the series, 3–0.

†: No-hitter by Roy Halladay

This was the first postseason meeting between these two teams since the 1976 NLCS, which the Reds won in a sweep en route to winning back-to-back titles. This time, the Phillies returned the favor, sweeping the Reds to advance to the NLCS for the third year in a row.

This series was notable for a no-hitter thrown by Roy Halladay in Game 1, the first no-hitter in the postseason since Don Larsen's perfect game in the 1956 World Series.[21] In Game 2, the Reds held a 4–0 lead, but the Phillies would rally with seven unanswered runs in the bottom the fifth, sixth, seventh, and eighth respectively to win and take a 2–0 series lead headed to Cincinnati. Cole Hamels pitched a complete-game shutout for the Phillies in Game 3 to complete the sweep.

This was the last playoff series won by the Phillies until 2022.

San Francisco won the series, 3–1.

This was the second postseason meeting between these two teams. The Giants defeated the Braves in four games to return to the NLCS for the first time since 2002.

Giants' ace Tim Lincecum pitched a complete-game shutout in Game 1, while the Braves evened the series with a one-run victory in Game 2. In Atlanta, the Giants narrowly prevailed in Game 3 to take a 2–1 series lead after being down to their last out while trailing in the top of the ninth. Giants' rookie pitcher Madison Bumgarner helped close out the series in Game 4 in what would be his first of many postseason wins.

Texas won the series, 4–2.

This was the fourth postseason meeting between the Rangers and Yankees. They had previously met in the ALDS in 1996, 1998, and 1999, which were all won by the Yankees. This time, the Rangers returned the favor, defeating the Yankees in six games to advance to the World Series for the first time in franchise history (in the process denying a rematch of the 1962 World Series).

Both teams split the first two games in Arlington — the Yankees overcame a 5–0 lead in Game 1 to win 6–5, and in Game 2, the Rangers won their first home postseason game in franchise history. When the series moved to the Bronx, the Rangers blew out the Yankees, 8–0, partly thanks to another solid pitching performance from Cliff Lee. The Rangers blew out the Yankees again in Game 4, 10–3, to take a 3–1 series lead. CC Sabathia and the Yankees' bullpen helped send the series back to Arlington with a 7–2 victory in Game 5. In Game 6, with the game tied at one going into the bottom of the fifth, Vladimir Guerrero and Nelson Cruz put the Rangers in the lead for good with a four-run fifth, effectively securing the pennant.

The Rangers would win the AL pennant again the next year against the Detroit Tigers in six games. The Yankees returned to the ALCS in 2012, but were swept by the Tigers.

San Francisco won the series, 4–2.

The Giants upset the heavily favored Phillies in six games to return to the World Series for the first time since 2002.

Both teams split the first two games in Philadelphia - Tim Lincecum and Giants' closer Brian Wilson led the Giants to an upset win in Game 1, while Roy Oswalt helped lead the Phillies to victory in Game 2 by pitching seven scoreless innings. When the series shifted to San Francisco, the Giants shut out the Phillies in Game 3 by a 3–0 score thanks to a solid pitching performance from Matt Cain. In Game 4, the Giants overcame multiple attempts by the Phillies offense to even the series, as they prevailed by one run in the bottom of the ninth inning to take a 3–1 series lead. The Phillies sent the series back to Philadelphia with a 4–2 victory in Game 5. In Game 6, the Phillies jumped out to an early 2–0 lead in the bottom of the first, however the Giants tied the game with a two-run third inning. No team scored a run until the top of the eighth, when San Francisco's Juan Uribe hit a solo home run to put the Giants in the lead for good. Brian Wilson then struck out Philadelphia's Ryan Howard looking in the bottom of the ninth to clinch the pennant for the Giants.

This was the last NLCS appearance by the Phillies until 2022. The Giants would win two more NL pennants during the decade, in 2012 and 2014, both against the St. Louis Cardinals.

San Francisco won the series, 4–1.

This was the eighth postseason meeting in North American sports history between teams from the San Francisco Bay Area and the Dallas-Ft. Worth Metroplex. The other meetings were in the NFL Playoffs, during the heyday of the 49ers–Cowboys rivalry from 1971 to 1995.

In the first World Series ever played in the Dallas-Ft. Worth Metroplex, the Giants defeated the Rangers in five games to win their first World Series title since 1954, ending the Curse of Coogan's Bluff.

In Game 1, the Giants prevailed in an offensive duel by an 11–7 score. In Game 2, the Giants blew out the Rangers, 9–0, thanks to another solid pitching performance from Matt Cain. When the series moved to Arlington, the Rangers won Game 3 by a 4–2 score to win their first World Series game. In Game 4, Madison Bumgarner helped the Giants shut out the Rangers again to take a 3–1 series lead, as Bumgarner became the fourth-youngest pitcher to win a World Series game at the age of 21. In Game 5, thanks to a solid pitching effort from Tim Lincecum and closer Brian Wilson, the Giants prevailed by a 3–1 score to end their long World Series title drought.

This was the first championship won by a team from the San Francisco Bay Area since 1995, when the San Francisco 49ers won Super Bowl XXIX. It was also the first World Series title for the Bay Area since 1989, which was won by the Oakland Athletics, who ironically swept the Giants that year.

This marked the start of a dynasty for the Giants, as they would win the World Series again in 2012 against the Detroit Tigers, and in 2014 against the Kansas City Royals. The Rangers would return to the World Series the next year, but fell to the St. Louis Cardinals in seven games.