2019 Major League Baseball postseason

1. Houston Astros – AL West champions, AL best record, MLB best record 107–55[2]
2. New York Yankees – AL East champions, 103–59[3]
3. Minnesota Twins – AL Central champions, 101–61[4]
4. Oakland Athletics – 97–65[5]
5. Tampa Bay Rays – 96–66[6]

1. Los Angeles Dodgers – NL West champions, NL best record, 106–56[7]
2. Atlanta Braves – NL East champions, 97–65[8]
3. St. Louis Cardinals – NL Central champions, 91–71[9]
4. Washington Nationals – 93–69[10]
5. Milwaukee Brewers – 89–73[11]

The Rays defeated the Athletics 5–1 to advance to the ALDS for the first time since 2013.

The Nationals rallied from an early 3–0 deficit to defeat the Brewers by a final score of 4–3 to advance to the NLDS.

Houston won the series, 3–2.

This was the first postseason meeting between the Astros and Rays. The Astros defeated the Rays in five games to return to the ALCS for the third year in a row. Both teams would meet again in the 2020 ALCS, which the Rays won in seven games despite the Astros coming back from a 3–0 series deficit to force a seventh game.

New York won the series, 3–0.

This was the sixth postseason match-up between Minnesota and New York. The previous five meetings were in the ALDS in 2003, 2004, 2009, and 2010, as well as the 2017 AL Wild Card Game — with the Yankees winning each of those prior meetings. This was just the second time the ALDS featured a match-up of two 100-win teams, following the 2018 ALDS between the Yankees and Red Sox.

The Yankees again swept the Twins to advance to the ALCS for the second time in three years. The loss gave Minnesota its 16th straight postseason defeat, 13 of those in games against the Yankees; and their 28th straight year without winning the title.[20]

Washington won the series, 3–2.

This was the third postseason meeting between these two teams. The Nationals upset the 106-win Dodgers in five games to return to the NLCS for the first time since 1981, when the team was then known as the Montreal Expos.

The Dodgers won Game 1 in a 6-0 shutout thanks to a solid pitching performance from Walker Buehler. In Game 2, Stephen Strasburg out-dueled Clayton Kershaw as the Nationals prevailed by two runs to even the series. When the series shifted to the nation's capital, the Dodgers blew out the Nationals in Game 3 to regain the series lead. Max Scherzer pitched seven solid innings in Game 4 as the Nationals won 6-1 to even the series headed back to Los Angeles. In Game 5, the Dodgers jumped out to an early 3-0 lead, but it would not hold as the Nationals put up three unanswered runs in the sixth and eighth innings respectively to tie the game. Howie Kendrick would then win the series for the Nationals in the top of the tenth inning with a grand slam, giving the Nationals a 7-3 victory.

The Dodgers would redeem themselves the following season as they would go on to win the 2020 World Series against the Tampa Bay Rays.

St. Louis won the series, 3–2.

This was the fifth postseason meeting between the Cardinals and Braves. The Cardinals defeated the Braves in five games to advance to the NLCS for the first time since 2014. With the win, the Cardinals moved up to 4–1 against the Braves in the postseason, having won in 1982, 2000, and 2012.

Houston won the series, 4–2.

This was the third postseason meeting between the Yankees and Astros. The previous two meetings (2015, 2017) were won by the Astros. History once again repeated itself, and the Astros defeated the Yankees in six games to return to the World Series for the second time in three years.

Masahiro Tanaka pitched six shutout innings as the Yankees blew out the Astros 7–0 in Game 1. In Game 2, the Astros prevailed after 11 innings thanks to a walk-off home run from Carlos Correa. In the Bronx, the Astros stole Game 3 on the road thanks to a solid pitching performance from Gerrit Cole. The Astros convincingly won Game 4 by an 8–3 score to take a 3–1 series lead. The Yankees would send the series back to Houston with a 4–1 win in Game 5, but the Astros ultimately capped off the series with a walk-off two-run home run by José Altuve off Aroldis Chapman in the bottom of the ninth inning of Game 6, securing the pennant.

The Astros returned to the ALCS the next year, but fell to the Tampa Bay Rays in seven games. They would win their next pennant in 2021, against the Boston Red Sox in six games.

With the series loss, this marked the first decade since the 1910s that the Yankees failed to win the AL pennant. The Astros and Yankees would meet in the ALCS again in 2022, which the Astros won in a sweep.

Washington won the series, 4–0.

This was the second postseason meeting between the Nationals and Cardinals. This NLCS marked the first time that the Nationals franchise had ever played in a seven-game playoff series. The Nationals swept the Cardinals to reach the World Series for the first time in franchise history.

This series was heavily lopsided in favor of the Nationals. Aníbal Sánchez pitched seven solid innings as the Nationals shut out the Cardinals 2–0 to take Game 1 on the road. The Nationals would also win Game 2 thanks to a solid pitching performance from Max Scherzer. By holding the Cardinals hitless through the first five innings of each of their starts, Scherzer and Sánchez repeated a feat they accomplished in Games 1 and 2 of the 2013 ALCS as members of the Detroit Tigers, a feat no other pair of pitchers has ever accomplished in the postseason.[41] When the series shifted to the nation's capital, the Nationals blew out the Cardinals in Game 3 to take a 3–0 series lead. In Game 4, the Nationals jumped out to a 7–0 lead early, and despite the Cardinals cutting their lead to three after the fifth inning, the Nationals held on to secure their first and only NL pennant.

As of 2023, this is the last time both the Nationals and Cardinals have appeared in the NLCS.

Washington won the series, 4–3.

This was the second World Series to feature two expansion teams, as well as the first World Series since 1933 to come to Washington, D.C., when the Washington Senators fell to the New York Giants in five games. In the first championship series in the history of North American sports in which neither team won a home game, the Nationals pulled off one of the biggest upsets in World Series history, defeating the heavily-favored Astros in seven games.

The Nationals took Game 1 narrowly, and blew out the Astros in Game 2 to go up 2–0 in the series heading back to Washington, D.C. The Astros held the Nationals to one run in each of the next three games to take a 3–2 series lead going back to Houston. In Game 6, the Nationals blew out the Astros to force a seventh game. The Astros held a 2–0 lead going into the top of the seventh, when the Nationals’ Anthony Rendon hit a solo home run to cut the Astros’ lead to one. Then, Howie Kendrick hit a two-run home run to put the Nationals in the lead for good. The Nationals then scored three more unanswered runs in the top of the eighth and ninth innings to complete a major upset and secure the title.

It was the first World Series title in franchise history for the Nationals, as well as the first World Series title for the nation's capital since 1924, when the Senators defeated the Giants in seven games. Despite the win, no MLB team from the nation's capital had won a home game in the World Series since 1933.

Along with the Washington Capitals winning the 2018 Stanley Cup Finals, the Nationals and Capitals brought the first major league championships to D.C. since 1992, when the Washington Redskins won Super Bowl XXVI.

To date, this is the last postseason appearance by the Nationals franchise. The Astros returned to the World Series in 2021, but they were defeated by the Atlanta Braves in six games. The Astros would win their next championship in 2022 over the Philadelphia Phillies in six games.