2021 WTA Lyon Open

• Clara Tauson def. Viktorija Golubic 6–4, 6–1.

This was Tauson's first WTA singles title.

• Viktória Kužmová / Arantxa Rus def. Eugenie Bouchard / Olga Danilović 3–6, 7–5, [10–7].

¹Qualifiers prize money is also the Round of 32 prize money.
*per team

Country	Player	Ranking1	Seed
RUS	Ekaterina Alexandrova	33	1
FRA	Fiona Ferro	45	2
FRA	Caroline Garcia	46	3
FRA	Kristina Mladenovic	51	4
FRA	Alizé Cornet	58	5
ROU	Sorana Cîrstea	67	6
ESP	Paula Badosa	73	7
NED	Arantxa Rus	78	8

• ¹ Rankings as of 22 February 2021.[1]

The following players received wildcards into the main draw:

• Eugenie Bouchard
• Clara Burel
• Harmony Tan

The following players received entry into the main draw using a protected ranking:

• Mihaela Buzărnescu
• Vera Lapko

The following players received entry from the qualifying draw:

• Magdalena Fręch
• Margarita Gasparyan
• Giulia Gatto-Monticone
•    Viktorija Golubic
• Tereza Martincová
• Clara Tauson

Before the tournament

• Zarina Diyas → replaced by Katarzyna Kawa
• Kirsten Flipkens → replaced by    Stefanie Vögele
• Coco Gauff → replaced by Irina Bara
• Kaja Juvan → replaced by Katarina Zavatska
• Marta Kostyuk → replaced by Greet Minnen
• Kateryna Kozlova → replaced by Océane Dodin
• Nadia Podoroska → replaced by Wang Xiyu

Country	Player	Country	Player	Rank1	Seed
SVK	Viktória Kužmová	NED	Arantxa Rus	130	1
JPN	Makoto Ninomiya	CZE	Renata Voráčová	132	2
USA	Kaitlyn Christian	USA	Sabrina Santamaria	146	3
RUS	Ekaterina Alexandrova	RUS	Yana Sizikova	226	4

• Rankings as of February 8, 2021.

The following pairs received wildcards into the doubles main draw:

• Loïs Boisson / Juline Fayard
• Amandine Hesse / Elixane Lechemia

The following pairs received entry into the doubles main draw using protected rankings:

• Vera Lapko / Aliaksandra Sasnovich
• Alexandra Panova / Rosalie van der Hoek

Before the tournament

• Natela Dzalamidze / Cornelia Lister → replaced by Margarita Gasparyan / Cornelia Lister