23S rRNA (guanine1835-N2)-methyltransferase

23S rRNA (guanine1835-N2)-methyltransferase (EC 2.1.1.174, ygjO (gene), rlmG (gene), ribosomal RNA large subunit methyltransferase G) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine1835 in 23S rRNA S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA
23S rRNA (guanine1835-N2)-methyltransferase
Identifiers
EC no.2.1.1.174
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.

References

  1. Sergiev PV, Lesnyak DV, Bogdanov AA, Dontsova OA (November 2006). "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA". Journal of Molecular Biology. 364 (1): 26–31. doi:10.1016/j.jmb.2006.09.008. PMID 17010380.
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