24-Methylenelophenol

24-Methylenelophenol, or Gramisterol, also called 4α-Methyl-5α-ergosta-7,24(28)-dien-3β-ol is a Metabolic intermediate of sterol biosynthesis of plants and fungis,[1] can be converted from 4α-Methylfecosterol by enzyme HYD1 and converted to (Z)-24-ethylidenelophenol by 24-methylenesterol C-methyltransferase.[2]

24-Methylenelophenol
Identifiers
3D model (JSmol)
3655840
ChEBI
ChemSpider
KEGG
  • InChI=1S/C29H48O/c1-18(2)19(3)8-9-20(4)23-12-13-25-22-10-11-24-21(5)27(30)15-17-29(24,7)26(22)14-16-28(23,25)6/h10,18,20-21,23-27,30H,3,8-9,11-17H2,1-2,4-7H3/t20-,21+,23-,24+,25+,26+,27+,28-,29+/m1/s1
    Key: RSMKYRDCCSNYFM-AAGDOFLISA-N
  • C[C@@H]1[C@H](CC[C@]2([C@H]1CC=C3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4[C@H](C)CCC(=C)C(C)C)C)C)O
Properties
C29H48O
Molar mass 412.702 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Ullah, H; Khan, A; Rehman, NU; Halim, SA; Khan, H; Khan, I; Csuk, R; Al-Rawahi, A; Al-Hatmi, S; Al-Harrasi, A (24 April 2020). "Lophenol and lathosterol from resin of Commiphora kua possess hepatoprotective effects in vivo". Journal of Ethnopharmacology. 252: 112558. doi:10.1016/j.jep.2020.112558. PMID 31926985. S2CID 210166705.
  2. Kuchta, T; Bartková, K; Kubinec, R (30 November 1992). "Ergosterol depletion and 4-methyl sterols accumulation in the yeast Saccharomyces cerevisiae treated with an antifungal, 6-amino-2-n-pentylthiobenzothiazole". Biochemical and Biophysical Research Communications. 189 (1): 85–91. doi:10.1016/0006-291x(92)91529-y. PMID 1449509.
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