2alpha-hydroxytaxane 2-O-benzoyltransferase
In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase (EC 2.3.1.166) is an enzyme that catalyzes the chemical reaction
- benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III CoA + 10-deacetylbaccatin III
| 2-alpha-hydroxytaxane 2-O-benzoyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.166 | ||||||||
| CAS no. | 329318-50-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase. This enzyme is also called benzoyl-CoA:taxane 2alpha-O-benzoyltransferase. This enzyme participates in diterpenoid biosynthesis.
References
- Walker K, Croteau R (2000). "Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13591–6. Bibcode:2000PNAS...9713591W. doi:10.1073/pnas.250491997. PMC 17620. PMID 11095755.
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