3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
In enzymology, a 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine S-adenosyl-L-homocysteine + (S)-reticuline
| 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.116 | ||||||||
| CAS no. | 132084-81-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-hydroxy-N-methyl-(S)-coclaurine, whereas its two products are S-adenosylhomocysteine and (S)-reticuline.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.
References
- Frenzel T, Zenk MH (1990). "S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway". Phytochemistry. 29 (11): 3505–3511. doi:10.1016/0031-9422(90)85265-H.
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