Mutagen X

Mutagen X
Names
	IUPAC name 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one
	Other names Mutagen X; MX
Identifiers
CAS Number	77439-76-0 ;
3D model (JSmol)	Interactive image;
ChemSpider	48451 ;
EC Number	253-575-7;
KEGG	C19205 ;
PubChem CID	53665;
UNII	SSD7YR4366 ;
CompTox Dashboard (EPA)	DTXSID6020276 ;
	InChI InChI=1S/C5H3Cl3O3/c6-2-1(3(7)8)4(9)11-5(2)10/h3-4,9H Key: WNTRMRXAGJOLCU-UHFFFAOYSA-N ; InChI=1/C5H3Cl3O3/c6-2-1(3(7)8)4(9)11-5(2)10/h3-4,9H Key: WNTRMRXAGJOLCU-UHFFFAOYAU;
	SMILES O=C1OC(O)C(C(Cl)Cl)=C1Cl;
Properties
Chemical formula	C5H3Cl3O3
Molar mass	217.43 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Mutagen X (MX), or 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one, is a byproduct of the disinfection of water by chlorination. MX is produced by reaction of chlorine with natural humic acids.

MX is found in chlorinated drinking water all over the world and is an environmental carcinogen that is known to cause several types of cancer in rats when present in large enough concentrations.[1] It is listed by the International Agency for Research on Cancer as a group 2B carcinogen meaning it is "possibly carcinogenic to humans". Although the concentration of MX in drinking water is typically 100- to 1000-fold lower than other common byproducts of water chlorination such as trihalomethanes, MX might play a role in the increased cancer risks that have been associated with the consumption of chlorinated water because of its potency in inducing DNA damage.[2]

References

Yuan, Jing; Liu, Hui; Zhou, Li-Hong; Zou, Ya-Lin; Lu, Wen-Qing (2006). "Oxidative stress and DNA damage induced by a drinking-water chlorination disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in mice". Mutation Research. 609 (2): 129–136. doi:10.1016/j.mrgentox.2006.05.011. PMID 16952480.
McDonald, Thomas A.; Komulainen, Hannu (2005). "Carcinogenicity of the chlorination disinfection by-product MX". Journal of Environmental Science and Health, Part C. C23 (2): 163–214. doi:10.1080/10590500500234988. PMID 16291527.

External links

California Office of Environmental Health Hazard Assessment report on MX

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[1] Yuan, Jing; Liu, Hui; Zhou, Li-Hong; Zou, Ya-Lin; Lu, Wen-Qing (2006). "Oxidative stress and DNA damage induced by a drinking-water chlorination disinfection byproduct 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in mice". Mutation Research. 609 (2): 129–136. doi:10.1016/j.mrgentox.2006.05.011. PMID 16952480.

[2] McDonald, Thomas A.; Komulainen, Hannu (2005). "Carcinogenicity of the chlorination disinfection by-product MX". Journal of Environmental Science and Health, Part C. C23 (2): 163–214. doi:10.1080/10590500500234988. PMID 16291527.