3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
In enzymology, a 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase (EC 2.1.1.99) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + 3-hydroxy-16-methoxy-2,3-dihydrotabersonine S-adenosyl-L-homocysteine + deacetoxyvindoline
| 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.99 | ||||||||
| CAS no. | 113478-40-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are S-adenosyl methionine and 3-hydroxy-16-methoxy-2,3-dihydrotabersonine, whereas its two products are S-adenosylhomocysteine and deacetoxyvindoline.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase. Other names in common use include 16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase, NMT, 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase, S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine, and N-methyltransferase. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.
References
- Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM (2006). "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics. 6 (9): 2726–32. doi:10.1002/pmic.200500419. PMID 16526094.