Glyceraldehyde 3-phosphate

Glyceraldehyde 3-phosphate
Names
	IUPAC name 2-hydroxy-3-oxopropyl dihydrogen phosphate
Identifiers
CAS Number	591-59-3 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	1725008
ChEBI	CHEBI:17138 ;
ChEMBL	ChEMBL1232918;
ChemSpider	709 (Racemic) ; 393755 (L isomer) ; 388314 (D isomer) ;
DrugBank	DB02263;
ECHA InfoCard	100.008.839
EC Number	209-721-7;
KEGG	C00661 ; C00118 ;
MeSH	Glyceraldehyde+3-Phosphate
PubChem CID	729;
UNII	7466PL1110 ;
CompTox Dashboard (EPA)	DTXSID40861814 ;
	InChI InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h1,3,5H,2H2,(H2,6,7,8) Key: LXJXRIRHZLFYRP-UHFFFAOYSA-N ; InChI=1/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h1,3,5H,2H2,(H2,6,7,8) Key: LXJXRIRHZLFYRP-UHFFFAOYAH;
	SMILES C([C@H](C=O)O)OP(=O)(O)O;
Properties
Chemical formula	C3H7O6P
Molar mass	170.058
Melting point	102–104 °C [1]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Glyceraldehyde 3-phosphate, also known as triose phosphate or 3-phosphoglyceraldehyde and abbreviated as G3P, GA3P, GADP, GAP, TP, GALP or PGAL, is a metabolite that occurs as an intermediate in several central pathways of all organisms.[2][3] With the chemical formula H(O)CCH(OH)CH₂OPO₃^{^2-}, this anion is a monophosphate ester of glyceraldehyde.

An intermediate in both glycolysis and gluconeogenesis

Formation

D-glyceraldehyde 3-phosphate is formed from the following three compounds in reversible reactions:

Fructose-1,6-bisphosphate (F1,6BP), catalyzed by aldolase.

β-D-fructose 1,6-bisphosphate	fructose-bisphosphate aldolase	D-glyceraldehyde 3-phosphate		dihydroxyacetone phosphate
			+




	fructose-bisphosphate aldolase

Compound C05378 at KEGG Pathway Database. Enzyme 4.1.2.13 at KEGG Pathway Database. Compound C00111 at KEGG Pathway Database. Compound C00118 at KEGG Pathway Database.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Dihydroxyacetone phosphate (DHAP), catalyzed by triose phosphate isomerase.

Dihydroxyacetone phosphate	triose phosphate isomerase	D-glyceraldehyde 3-phosphate





	triose phosphate isomerase

Compound C00111 at KEGG Pathway Database.Enzyme 5.3.1.1 at KEGG Pathway Database.Compound C00118 at KEGG Pathway Database.

1,3-bisphosphoglycerate (1,3BPG), catalyzed by glyceraldehyde 3-phosphate dehydrogenase.

As a substrate

To produce 1,3-bisphospho-D-glycerate in glycolysis.

glyceraldehyde 3-phosphate	glyceraldehyde phosphate dehydrogenase		D-glycerate 1,3-bisphosphate

	NAD⁺ + P_i	NADH + H⁺

	NAD⁺ + P_i	NADH + H⁺

Compound C00118 at KEGG Pathway Database. Enzyme 1.2.1.12 at KEGG Pathway Database. Reaction R01063 at KEGG Pathway Database. Compound C00236 at KEGG Pathway Database.

D-glyceraldehyde 3-phosphate is also of some importance since this is how glycerol (as DHAP) enters the glycolytic and gluconeogenic pathways. Furthermore, it is a participant in and a product of the pentose phosphate pathway.

Interactive pathway map

|Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

An intermediate in photosynthesis

During plant photosynthesis, 2 equivalents of glycerate 3-phosphate (GP; also known as 3-phosphoglycerate) are produced by the first step of the light-independent reactions when ribulose 1,5-bisphosphate (RuBP) and carbon dioxide are catalysed by the rubisco enzyme. The GP is converted to D-glyceraldehyde 3-phosphate (G3P) using the energy in ATP and the reducing power of NADPH as part of the Calvin cycle. This returns ADP, phosphate ions Pi, and NADP+ to the light-dependent reactions of photosynthesis for their continued function. RuBP is regenerated for the Calvin cycle to continue.

G3P is generally considered the prime end-product of photosynthesis and it can be used as an immediate food nutrient, combined and rearranged to form monosaccharide sugars, such as glucose, which can be transported to other cells, or packaged for storage as insoluble polysaccharides such as starch.

Balance sheet

6 CO₂ + 6 RuBP (+ energy from 12 ATP and 12 NADPH) →12 G3P (3-carbon)

10 G3P (+ energy from 6 ATP) → 6 RuBP (i.e. starting material regenerated)

2 G3P → glucose (6-carbon).

In tryptophan biosynthesis

Glyceraldehyde 3-phosphate occurs as a byproduct in the biosynthesis pathway of tryptophan, an essential amino acid that cannot be produced by the human body.

In thiamine biosynthesis

Glyceraldehyde 3-phosphate occurs as a reactant in the biosynthesis pathway of thiamine (Vitamin B₁), another substance that cannot be produced by the human body.

References

"metabocard for Glycerol 3-phosphate".
Berg, Jeremy M.; Tymoczko, Stryer (2002). Biochemistry (5th ed.). New York: W.H. Freeman and Company. ISBN 0-7167-3051-0.
Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. ISBN 1-57259-153-6.

External links

D-Glyceraldehyde 3-phosphate and the reactions and pathways it participates in, from the KEGG PATHWAY Database
Glyceraldehyde 3-phosphate and the reactions and pathways it participates in, from the KEGG PATHWAY Database

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[WikiPathways-4] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[hmdb-1] "metabocard for Glycerol 3-phosphate".

[2] Berg, Jeremy M.; Tymoczko, Stryer (2002). Biochemistry (5th ed.). New York: W.H. Freeman and Company. ISBN 0-7167-3051-0.

[3] Nelson, D. L.; Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000. ISBN 1-57259-153-6.