4-chlorobenzoyl-CoA dehalogenase

In enzymology, a 4-chlorobenzoyl-CoA dehalogenase (EC 3.8.1.7) is an enzyme that catalyzes the chemical reaction

4-chlorobenzoyl-CoA + H2O 4-hydroxybenzoyl CoA + chloride
4-chlorobenzoyl-CoA dehalogenase
Identifiers
EC no.3.8.1.7
CAS no.141583-18-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are 4-chlorobenzoyl-CoA and H2O, whereas its two products are 4-hydroxybenzoyl CoA and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoyl CoA chlorohydrolase. This enzyme participates in 2,4-dichlorobenzoate degradation.

References

    • Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D (1992). "Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3". Biochemistry. 31 (24): 5605–10. doi:10.1021/bi00139a025. PMID 1610806.
    • Crooks GP, Copley SD (1994). "Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1". Biochemistry. 33 (38): 11645–9. doi:10.1021/bi00204a028. PMID 7918379.


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