4-chlorobenzoate dehalogenase
In enzymology, a 4-chlorobenzoate dehalogenase (EC 3.8.1.6) is an enzyme that catalyzes the chemical reaction
- 4-chlorobenzoate + H2O 4-hydroxybenzoate + chloride
| 4-chlorobenzoate dehalogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.8.1.6 | ||||||||
| CAS no. | 94047-11-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 4-chlorobenzoate and H2O, whereas its two products are 4-hydroxybenzoate and chloride.
This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is 4-chlorobenzoate chlorohydrolase. This enzyme is also called halobenzoate dehalogenase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BVQ, 1JXZ, and 1NZY.
References
- Müller R, Thiele J, Klages U, Lingens F (October 1984). "Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3". Biochemical and Biophysical Research Communications. 124 (1): 178–82. doi:10.1016/0006-291X(84)90933-1. PMID 6497878.
- Heppel LA, Porterfield VT (November 1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds". The Journal of Biological Chemistry. 176 (2): 763–9. PMID 18889931.
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