4-hydroxyacetophenone monooxygenase

In enzymology, a 4-hydroxyacetophenone monooxygenase (EC 1.14.13.84) is an enzyme that catalyzes the chemical reaction:

(4-hydroxyphenyl)ethan-1-one + NADPH + H+ + O2 O-acetylhydroquinone + NADP+ + H2O
4-hydroxyacetophenone monooxygenase
Identifiers
EC no.1.14.13.84
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The 4 substrates of this enzyme are (4-hydroxyphenyl)ethan-1-one, NADPH, H+, and O2, whereas its 3 products are hydroquinone acetate ester, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming). This enzyme is also called HAPMO. This enzyme participates in bisphenol a degradation.[1]

References

  1. Prasad Kotharu; Lynda Ellis; Shawn Balcome. "Bisphenol A Pathway Map". Biocatalysis/Biodegradation Database. Retrieved 2015-11-04.


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