6'-Deoxychalcone synthase

In enzymology, a 6'-deoxychalcone synthase (EC 2.3.1.170) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O
6'-Deoxychalcone synthase
Identifiers
EC no.2.3.1.170
CAS no.114308-23-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The 4 substrates of this enzyme are malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+, whereas its 5 products are CoA, isoliquiritigenin, CO2, NADP+, and H2O. Deoxychalcone synthase catalyzed activity is involved in the biosynthesis of retrochalcone and certain phytoalexins in the cells of Glycyrrhiza echinata (Russian licorice) and other leguminous plants.

This enzyme belongs to the family of transferases, to be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing).

References

    • Ayabe S, Udagawa A, Furuya T (1988). "NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract". Arch. Biochem. Biophys. 261 (2): 458–62. doi:10.1016/0003-9861(88)90362-1. PMID 3355160.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.