6-Hydroxykynurenic acid

6-Hydroxykynurenic acid is a constituent of ginkgo and an amino acid.[1] It is a derivative of kynurenic acid and has similarly been found to antagonize AMPA and NMDA, as well as their corresponding receptors.[2]

6-Hydroxykynurenic acid
Names
Preferred IUPAC name
4,6-Dihydroxyquinoline-2-carboxylic acid
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C10H7NO4/c12-5-1-2-7-6(3-5)9(13)4-8(11-7)10(14)15/h1-4,12H,(H,11,13)(H,14,15)
    Key: CQUUHDQRJWXDPY-UHFFFAOYSA-N
  • InChI=1/C10H7NO4/c12-5-1-2-7-6(3-5)9(13)4-8(11-7)10(14)15/h1-4,12H,(H,11,13)(H,14,15)
    Key: CQUUHDQRJWXDPY-UHFFFAOYAS
  • C1=CC2=C(C=C1O)C(=CC(=N2)C(=O)O)O
Properties
C10H7NO4
Molar mass 205.169 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. van Beek, Teris A (2002-08-16). "Chemical analysis of Ginkgo biloba leaves and extracts". Journal of Chromatography A. Chromatographic and Electrophoretic Analysis of Secondary Metabolites of Plants. 967 (1): 21–55. doi:10.1016/S0021-9673(02)00172-3. ISSN 0021-9673. PMID 12219929.
  2. Weber, Marco; Dietrich, Dirk; Gräsel, Ines; Reuter, Gerhard; Seifert, Gerald; Steinhäuser, Christian (2001-12-20). "6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones: 6-Hydroxykynurenate blocks glutamate receptors". Journal of Neurochemistry. 77 (4): 1108–1115. doi:10.1046/j.1471-4159.2001.00340.x. PMID 11359876. S2CID 23178914.


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