AAAP family

The Amino Acid/Auxin Permease (AAAP) Family (TC# 2.A.18) is a family of secondary carrier proteins, a member of the APC Superfamily that includes hundreds of proteins from plants, animals, fungi and lower eukaryotes. Six AAAPs in A. thaliana are well characterized and transport neutral and charged amino acids with varying specificities and affinities.[1][2]

Function

Among animal AAAP family members are numerous growth regulating System A and System N isoforms, each exhibiting distinctive tissue and subcellular localizations. The different isoforms also exhibit different relative affinities for the amino acid substrates. Some catalyze H+ antiport and can function bidirectionally. Since Systems A are electrogenic which Systems N are not, the amino acid:cation stoichiometries may differ.[2][3][4][5]

References
  1. Fischer, WN; Loo, DD; Koch, W; Ludewig, U; Boorer, KJ; Tegeder, M; Rentsch, D; Wright, EM; Frommer, WB (March 2002). "Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids". Plant Journal. 29 (6): 717–31. doi:10.1046/j.1365-313x.2002.01248.x. PMID 12148530.
  2. Saier, MH Jr. "2.A.18 The Amino Acid/Auxin Permease (AAAP) Family". Transporter Classification Database. Saier Lab Bioinformatics Group.
  3. Chaudhry, FA; Krizaj, D; Larsson, P; Reimer, RJ; Wreden, C; Storm-Mathisen, J; Copenhagen, D; Kavanaugh, M; Edwards, RH (December 17, 2001). "Coupled and uncoupled proton movement by amino acid transport system N." EMBO Journal. 20 (24): 7041–51. doi:10.1093/emboj/20.24.7041. PMC 125789. PMID 11742981.
  4. Chaudhry, FA; Schmitz, D; Reimer, RJ; Larsson, P; Gray, AT; Nicoll, R; Kavanaugh, M; Edwards, RH (January 1, 2002). "Glutamine uptake by neurons: interaction of protons with system a transporters". Journal of Neuroscience. 22 (1): 62–72. doi:10.1523/JNEUROSCI.22-01-00062.2002. PMC 6757603. PMID 11756489.
  5. Varoqui, H; Zhu, H; Yao, D; Ming, H; Erickson, JD (February 11, 2000). "Cloning and functional identification of a neuronal glutamine transporter". Journal of Biological Chemistry. 275 (6): 4049–54. doi:10.1074/jbc.275.6.4049. PMID 10660562.

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