AADAC

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.[5][6]

AADAC
Identifiers
AliasesAADAC, CES5A1, DAC, arylacetamide deacetylase
External IDsOMIM: 600338 MGI: 1915008 HomoloGene: 37436 GeneCards: AADAC
EC number3.1.1.3
Orthologs
SpeciesHumanMouse
Entrez

13

67758

Ensembl

ENSG00000114771

ENSMUSG00000027761

UniProt

P22760

Q99PG0

RefSeq (mRNA)

NM_001086

NM_023383

RefSeq (protein)

NP_001077

NP_075872

Location (UCSC)Chr 3: 151.81 – 151.83 MbChr 3: 59.93 – 59.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000114771 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027761 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase". J Biol Chem. 269 (34): 21650–6. doi:10.1016/S0021-9258(17)31855-0. PMID 8063807.
  6. "Entrez Gene: AADAC arylacetamide deacetylase (esterase)".

Further reading



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