ACOT7

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.[5][6][7][8]

ACOT7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDsOMIM: 602587 MGI: 1917275 HomoloGene: 15780 GeneCards: ACOT7
Orthologs
SpeciesHumanMouse
Entrez

11332

70025

Ensembl

ENSG00000097021

ENSMUSG00000028937

UniProt

O00154

Q91V12

RefSeq (mRNA)
RefSeq (protein)

NP_009205
NP_863654
NP_863655
NP_863656

Location (UCSC)Chr 1: 6.26 – 6.39 MbChr 4: 152.26 – 152.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000097021 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028937 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.
  6. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
  7. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
  8. "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

Further reading


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