ACOT7

ACOT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQ2
Identifiers
Aliases	ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDs	OMIM: 602587 MGI: 1917275 HomoloGene: 15780 GeneCards: ACOT7
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	6,393,767 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	152,356,312 bp[2]
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; pons; ; endothelial cell; ; middle temporal gyrus; ; spinal ganglia; ; hypothalamus; ; superior frontal gyrus; ; frontal pole; ; nucleus accumbens;
	Top expressed in
	seminiferous tubule; ; anterior horn of spinal cord; ; medial dorsal nucleus; ; facial motor nucleus; ; medulla oblongata; ; medial vestibular nucleus; ; pontine nuclei; ; dorsal tegmental nucleus; ; habenula; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; fatty-acyl-CoA binding; protein homodimerization activity; carboxylic ester hydrolase activity; long-chain fatty acyl-CoA binding; protein binding; hydrolase activity; acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; thiolester hydrolase activity;
Cellular component	cytosol; nucleoplasm; mitochondrion; extracellular exosome; cytoplasm;
Biological process	medium-chain fatty acid biosynthetic process; medium-chain fatty-acyl-CoA catabolic process; long-chain fatty-acyl-CoA catabolic process; coenzyme A biosynthetic process; palmitic acid biosynthetic process; acyl-CoA metabolic process; lipid metabolism; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	11332
	70025
	ENSG00000097021
	ENSMUSG00000028937
	O00154
	Q91V12
NM_181866; NM_007274; NM_181862; NM_181863; NM_181864;
	NM_181865
NM_001146057; NM_001146058; NM_133348; NM_001369273; NM_001369274;
	NM_001369275; NM_001369276
	NP_009205; NP_863654; NP_863655; NP_863656
NP_001139529; NP_001139530; NP_579926; NP_001356202; NP_001356203;
	NP_001356204; NP_001356205
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.[5][6][7][8]

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.[8]

References

GRCh38: Ensembl release 89: ENSG00000097021 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028937 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.
Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
"Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

External links

Human ACOT7 genome location and ACOT7 gene details page in the UCSC Genome Browser.

Yamada J (2006). "Long-chain acyl-CoA hydrolase in the brain". Amino Acids. 28 (3): 273–8. doi:10.1007/s00726-005-0181-1. PMID 15731883. S2CID 10678899.
Yamada J, Kuramochi Y, Takagi M, et al. (2003). "Human brain acyl-CoA hydrolase isoforms encoded by a single gene". Biochem. Biophys. Res. Commun. 299 (1): 49–56. doi:10.1016/S0006-291X(02)02587-1. PMID 12435388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yang JW, Czech T, Yamada J, et al. (2005). "Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy". Amino Acids. 27 (3–4): 269–75. doi:10.1007/s00726-004-0138-9. PMID 15592755. S2CID 2832201.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000097021 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028937 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10578051-5] Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.

[pmid16103133-6] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.

[entrez-8] "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

ACOT7

References

External links

Further reading